Results 101 to 110 of about 1,830,949 (244)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Expansión internacional de cadenas hoteleras españolas [PDF]
, 2017 La expansión internacional de las cadenas hoteleras españolas no sólo ha registrado un crecimiento continuo sino también una transformación permanente. Durante esta última década, las cadenas han expandido y diversificado el abanico de países en los que ...
Muñoz Prados, María +1 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
STRUCTURAL CHANGE IN EXPORTS AND ECONOMIC GROWTH: COINTEGRATION AND CAUSALITY ANALYSIS FOR SPAIN (1961-2000) [PDF]
In this paper the Spanish export-led growth hypothesis is re-examined from the trade liberalisation process initiated four decades ago. For this purpose it is taken under consideration both the export expansion and the progression from "traditional ...
Jacint Balaguer +1 more
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Estrategias Comunicativas de expansión en alumnos de nivel intermedio [PDF]
, 2009 El objetivo de este artículo es presentar algunas Estrategias Comunicativas (EC) de expansión que usan los alumnos de nivel intermedio de la Facultad de Lenguas de la Universidad Autónoma del Estado de México, tanto en la producción escrita en francés ...
Grondin, Georgia M. K. +3 more
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Crisis y expansión en las relaciones comerciales hispano-rusas [PDF]
, 2012 En este trabajo se analizan las relaciones comerciales entre España y Rusia durante el periodo 2007-2011. En primer lugar, se estudian las relaciones comerciales globales entre ambos países y se destaca que Rusia constituye un socio comercial de gran ...
Sánchez Andrés, Antonio
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source