Results 41 to 50 of about 172,982 (313)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Stochastic Expansion Planning Model for a Coordinated Natural Gas and Electricity Networks Coupled With Gas-Fired Generators, Power-to-Gas Facilities, and Renewable Power

IEEE Access
This paper presents a stochastic expansion planning model for coordinated natural gas and electricity networks, incorporating gas-fired generators, Power-to-Gas facilities, and renewable power sources.
Patrick Sunday Onen, Rana H. A. Zubo, Nazar T. Ali, Geev Mokryani, Jian-Ping Li, Raed Abd-Alhameed   +5 more
doaj   +1 more source

Optimal Expansion Co-Planning of Reconfigurable Electricity and Natural Gas Distribution Systems Incorporating Energy Hubs

Energies, 2017
In a carbon-constrained world, natural gas with low emission intensity plays an important role in the energy consumption area. Energy consumers and distribution networks are linked via energy hubs.
Xianzheng Zhou, Chuangxin Guo, Yifei Wang, Wanqi Li   +3 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Active Distribution Network Expansion Planning Based on Wasserstein Distance and Dual Relaxation

Energies
In the future, a high proportion of distributed generations (DG) will be integrated into the distribution network. The existing active distribution network (ADN) planning methods have not fully considered multiple uncertainties, differentiated regulation
Jianchu Liu, Xinghang Weng, Mingyang Bao, Shaohan Lu, Changhao He   +4 more
doaj   +1 more source

Integrated generation- transmission expansion planning: a review of the state of the art

, 2016
In the last decade a great number of research works have approached the power systems planning problem by coordinating in a single optimization problem the generation expansion planning (GEP) and the transmission expansion planning (TEP).
Saldarriaga-Zuluaga, Sergio D., Galeano, Nicolás M., Sergio D. Saldarriaga-Zuluaga, López Lezama, Jesús María, Muñoz Galeano, Nicolás, Jesús M. López-Lezama, Nicolás M. Galeano, Saldarriaga Zuluaga, Sergio D., Lopez-Lezama, Jesús M.   +8 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Optimized Planning of Distribution Grids Considering Grid Expansion, Battery Systems and Dynamic Curtailment

Energies, 2021
The increasing integration of renewable energies into the grid is calling for the expansion of the power transport capacities in the distribution system.
Ouafa Laribi, Krzysztof Rudion
doaj   +1 more source

An advanced decision process for capacity expansion in manufacturing networks [PDF]

, 2008
Manufacturing companies develop multiple production sites for various reasons from cheaper labour to access to local markets. Expansion of capacity in such a manufacturing network is a complex decision and requires consideration of multiple factors ...
Julka, Nirupam
core