Results 51 to 60 of about 172,982 (313)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Power System Planning Considering Extreme Weather Events and Stability Criteria

IEEE Access
The Intergovernmental Panel on Climate Change Sixth Assessment Report highlights severe climate change (CC) consequences, including increased extreme weather events (EWE) such as extreme winds, heat waves, heavy rains, floods, and fires. Integrating this
Pedro Gutierrez, Rodrigo Palma-Behnke, Claudia Rahmann, Angela Flores-Quiroz   +3 more
doaj   +1 more source

Transmission Network Expansion Planning Considering Line Switching

IEEE Access, 2020
Commonly, in the transmission network expansion planning (TNEP) problem, the objective is to define the minimal-cost investment in new transmission devices, e.g., the transmission lines and transformers, for the system to operate adequately in a planning
Marco Meneses, Edgar Nascimento, Leonardo H. Macedo, Ruben Romero   +3 more
doaj   +1 more source

Urban expansion in Zanzibar City, Tanzania: Analyzing quantity, spatial patterns and effects of alternative planning approaches [PDF]

, 2018
Rapid urbanization and urban area expansion of sub-Saharan Africa are megatrends of the 21st century. Addressing environmental and social problems related to these megatrends requires faster and more efficient urban planning that is based on measured ...
Muhammad, Muhammad J., Luoto, Miska, Kukkonen, Markus O., Markus O. Kukkonen, Muhammad J. Muhammad, Käyhkö, Niina, Miska Luoto, Niina Käyhkö   +7 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The Impact of Risk Preference in Decision Behavior on Urban Expansion Morphology

Complexity, 2021
With the rapid development of urbanization, the urban expansion morphology has been changing with complex driving mechanisms behind the urban evolution process. This article simulates the results of urban land development contingent upon decision-makers’
Zhangwei Lu, Lihua Xu, Yaqi Wu, Yijun Shi, Jinyang Deng, Xiaoqiang Shen   +5 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Coal Phase-Out and Carbon Tax Analysis with Long-Term Planning Models: A Case Study for the Chilean Electric Power System

Energies
Large CO2 emissions constitute a significant problem today due to their effect on climate change, and the need to design appropriate energy policies to mitigate their consequences and reduce emissions requires a detailed analysis of one of the main ...
Patricio Castillo, Matias Aguad, Álvaro Lorca, Samuel Cordova, Matias Negrete-Pincetic   +4 more
doaj   +1 more source

Market Oriented Transmission Expansion Planning

, 2021
The reform of electricity market in China has made the market participants more active, which has posed a series of challenges for the power system planning with high penetration of renewable energy.
Wang, Xiaolin,, Yan, Jinyue,
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source