Results 51 to 60 of about 3,647,280 (240)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Reinforcement Learning for Efficient Power Systems Planning: A Review of Operational and Expansion Strategies

open access: yesEnergies
The efficient planning of electric power systems is essential to meet both the current and future energy demands. In this context, reinforcement learning (RL) has emerged as a promising tool for control problems modeled as Markov decision processes (MDPs)
Gabriel Pesántez   +4 more
doaj   +1 more source

Measuring the Long-Term Uncertainty Effect Reduction on Transmission Expansion Planning [PDF]

open access: yesInternational Journal of Mathematical, Engineering and Management Sciences
Transmission expansion planning (TEP) is known as long-term study, which is related to the generation expansion pattern, i.e. where and how many new generation facilities will be constructed.
Payam Dalaliyan Miandoab   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

A Quantile-Based Approach for Transmission Expansion Planning

open access: yesIEEE Access, 2020
Transmission expansion planning is an integral part of power system planning and consists of generating and selecting transmission proposals for maintaining sufficient transmission capacity to satisfy the electric load.
Jairo Cervantes, F. Fred Choobineh
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Flexible Transmission Network Planning Considering the Impacts of Distributed Generation [PDF]

open access: yes
The restructuring of global power industries has introduced a number of challenges, such as conflicting planning objectives and increasing uncertainties,to transmission network planners.
Junhua Zhao, John Foster
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Transmission and Generation Expansion Planning Considering Virtual Power Lines/Plants, Distributed Energy Injection and Demand Response Flexibility from TSO-DSO Interface

open access: yesEnergies
This article presents a computational model for transmission and generation expansion planning considering the impact of virtual power lines, which consists of the investment in energy storage in the transmission system as well as being able to determine
Flávio Arthur Leal Ferreira   +2 more
doaj   +1 more source

Concepts for Integrated Planning of Port Capacity- Application to Rotterdam Expansion Plans

open access: yesPromet (Zagreb), 2006
Port planning is complicated due to many factors, includingthe existence of economies of scale in port expansion andthe fact that ports operate under competition.
Sander Dekker, Robert Verhaeghe
doaj   +1 more source

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