Results 181 to 190 of about 2,520,095 (363)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

When personality meets surprise: individual differences in memory for unexpected events. [PDF]

Front Psychol
Kafkas A, Westerman M, Cleto K, Sabaityte K, Sergi K.   +4 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Roles of administration route, expectation, and belief in placebos in a randomized controlled trial with open-label placebos. [PDF]

Sci Rep
Schaefer M, Liedtke C, Enge S.
europepmc   +1 more source

A composition of different $q$ nonextensive systems with the normalized expectation based on escort probability [PDF]

, 2006
Qiuping A. Wang, L. Nivanen, Alain Le Méhauté   +2 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Center-surround inhibition in expectation and its underlying computational and artificial neural network models. [PDF]

Elife
Huang L, Shen S, Sun Y, Ou S, Zhang RY, de Lange FP, Zhang X.   +6 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Uncovering the mechanism linking education expectation and suicide ideation among students in tertiary education: The mediating role of academic burnout, psychache, and hopelessness. [PDF]

PLoS One
Morshidi MI, Chew PKH, Suarez L.
europepmc   +1 more source

THU0445 ASSOCIATION BETWEEN PATIENT'S EXPECTATION AND SATISFACTION FOLLOWING TOTAL KNEE REPLACEMENT FOR OSTEOARTHRITIS [PDF]

, 2019
Maria Noviani, Julian Thumboo, Seng Jin Yeo, Steven Bak-Siew Wong, Vikki Wylde, Bibhas Chakraborty, Ngai Nung Lo, William Yeo, Hwei Chi Chong, Mann Hong Tan, Hee Nee Pang, Darren Keng Jin Tay, Ying Ying Leung   +12 more
openalex   +1 more source