Results 71 to 80 of about 1,818,388 (305)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The Calculus of Expected Loss: Backtesting Parameter-Based Expected Loss in a Basel II Framework [PDF]
, 2012 The dependency structure of credit risk parameters is a key driver for capital consumption and receives regulatory and scientific attention. The impact of parameter imperfections on the quality of expected loss (EL) in the sense of a fair, unbiased estimate of risk expenses however is barely covered.
openaire +2 more sources
The Error of Expected Loss Minimization [PDF]
Law, Probability and Risk, 2003 Considerable effort has been expended by legal scholars attempting to apply formal approaches such as Bayes’ Theorem or decision theory to various aspects of the litigation process. These efforts consistently fail adequately to account for the reality of the phenomenon being investigated. Most recently, Professor Kaye attempted to give another decision-
openaire +1 more source
Using Hermite Expansions for Fast and Arbitrarily Accurate Computation of the Expected Loss of a Loan Portfolio Tranche in the Gaussian Factor Model [PDF]
We propose a fast algorithm for computing the expected tranche loss in the Gaussian factor model with arbitrary accuracy using Hermite expansions. No assumptions about homogeneity of the portfolio are made.
Pavel Okunev
core
Theoretical Loss and Gambling Intensity (Revisited): A Response to Braverman et al. (2013)
, 2015 In this paper, we provide a brief response to Braverman and colleagues’ (2013) critique of our ‘Theoretical Loss’ metric as a measure of monetary gambling intensity (Auer & Griffiths, 2013; Auer, Schneeberger & Griffiths, 2012).
Auer, M, Griffiths, MD
core +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
The Operational Risk – Minimum Capital Requirements [PDF]
Theoretical and Applied Economics, 2009 This paper aims to present how to quantify the minimum capital requirement for operational risk using three approaches proposed by the Basel Committee to identify optimal allocation of capital, given that until recently to this risk has been allocated a ...
Gabriela Victoria Anghelache +1 more
doaj +1 more source
Pricing Excess-of-loss Reinsurance Contracts Against Catastrophic Loss [PDF]
This paper develops a pricing methodology and pricing estimates for the proposed Federal excess-of- loss (XOL) catastrophe reinsurance contracts.
J. David Cummins +2 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Tax Compliance and Rank-Dependent Expected Utility [PDF]
In this paper, we show that considering the classic Allingham and Sandmo (1972) tax compliance problem under Rank-Dependent Expected Utility (RDEU) axiomatics provides a simple explanation for the "excess" level of full compliance observed in empirical ...
Grégoire ROTA-GRAZIOSI +1 more
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