Results 61 to 70 of about 6,405,842 (302)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Neutrosophic Vision of the Expected Opportunity Loss Criterion (NEOL) Decision Making Under Risk [PDF]

Neutrosophic Sets and Systems
One of the major challenges facing decision-makers at the present time is obtaining complete information about the issue under study, due to the unstable conditions of the work environment that are beyond the control of decision-makers, which requires ...
Maissam Jdid, Florentin Smarandache
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Restrained Expectations in Late Pregnancy Following Loss [PDF]

Journal of Obstetric, Gynecologic & Neonatal Nursing, 2007
To describe women's late pregnancy after loss experiences (from 25 weeks gestation to birth), document the timing and frequency of their common discomforts and events, and explore changes in these experiences over time.A longitudinal, qualitative study of pregnancy calendar entries and field notes.Prenatal care providers and community canvassing in ...
Denise, Côté-Arsenault, Kara L, Donato
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Bayesian and E-Bayesian Estimation for the Generalized Rayleigh Distribution under Different Forms of Loss Functions with Real Data Application

Journal of Mathematics, 2023
This paper investigates the estimation of an unknown shape parameter of the generalized Rayleigh distribution using Bayesian and expected Bayesian estimation techniques based on type-II censoring data.
E. M. Eldemery, A. M. Abd-Elfattah, K. M. Mahfouz, Mohammed M. El Genidy   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Improving Credit Risk Assessment in Uncertain Times: Insights from IFRS 9

Risks
This study highlights the superior performance of Bayesian Model Averaging (BMA) in credit risk modeling under IFRS 9, particularly during economic uncertainty, such as the COVID-19 pandemic. Using granular bank-level data from Malta, spanning 2017–2023,
Petr Jakubik, Saida Teleu
doaj   +1 more source

New expected loss impairment model – a challenge for the banks in Bulgaria [PDF]

Икономика и компютърни науки, 2017
This article introduces some of the leading works on loan impairment published by supervisory authorities, auditing companies and researchers. It makes analysis of the impairment model on the basis of the expected credit losses introduced with the ...
Nadezhda Popova-Yosifova
doaj  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source