Results 91 to 100 of about 3,767,102 (309)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Blended Learning: Architectural Design Studio Experiences Using Housing in Istanbul

open access: yesJournal of Problem Based Learning in Higher Education, 2017
This paper presents how a blended learning pedagogic model is integrated into an architectural design studio for housing in the Faculty of Architecture in Istanbul Technical University adapting the problem-based learning process.
Yasemin Alkiser Bregger
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Design principles for interactive user experience through net art

open access: yes, 2007
The paper is to define interface design principles for web site design through user experiences in net art that will allow the designer to achieve truly user-centred design (UCD).
Park, Ji Yong
core  

Evaluating variables of patient experience and the correlation with design

open access: yes, 2017
The objective of this paper was to understand the variables of patient experience by analyzing recent and relevant evidence and to identify design solutions within the hospital environment that positively impact those variables.
Jennifer Schlimgen   +6 more
core   +2 more sources

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Integrated design and PLM applications in aeronautics product development [PDF]

open access: yes, 2009
Organised by: Cranfield UniversityWell known challenges in Aeronautic industry, namely reducing time to market, risks and development costs, could be reached thanks to innovative design methods supported by PLM technologies.
EYNARD, Benoit   +11 more
core  

Quality Time: Using experience-based co-design to capture emergency department staff experience

open access: yesThe Journal of Health Design, 2020
Researchers used experience-based co-design to capture emergency department staff experience. The outcomes were service improvement, increased staff engagement, and staff feeling heard and valued.
Melanie Gager   +3 more
doaj  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

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