Results 91 to 100 of about 7,548,819 (305)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Transcendental Experience as a Thought Experiment [PDF]
HORIZON. Studies in Phenomenology, 2015 In my article I would like to discuss a topic concerning the idea of mental experience as an experiment in the transcendental philosophy. One of the main problems of the humanities is that one can see a big difference between two branches of knowledge: human sciences and «exact» sciences.
openaire +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
International Journal of Clinical PracticeImproving patient experience is a key strategic priority in contemporary healthcare systems. A real-world observational implementation study with a quasiexperimental before–after design was conducted over a 6-month period in Argentina.
Julia Ismael +6 more
doaj +1 more source
Conducting experiments with Experiment Manager [PDF]
Proceedings of the 28th conference on Winter simulation - WSC '96, 1996 This tutorial demonstrates how to conduct experiments and perform analysis with Experiment Manager, CACI's tool for design and analysis of simulation experiments. Experiment Manager works in conjunction with SIMPROCESS and provides a quick and object oriented approach to designing simulation experiments. The tutorial will describe how to conduct a full
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Lessons for patient experience from the voices of pediatrics and children’s hospitals [PDF]
, 2018 This special issue on patient & family experience in children’s hospitals and pediatric care underlines pediatrics’ position as a leader in the experience journey.
Wolf, Jason A, PhD, CPXP
core +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Co-production in HIV research: a case study from the COVID-19 pandemic
Research Involvement and EngagementBackground Co-produced research is an approach where people with lived experience voluntarily engage as collaborators throughout the entire research process.
Vasiliki Papageorgiou +7 more
doaj +1 more source
CoRRThe scientific process is a means to turn the results of experiments into knowledge about the world in which we live. Much research effort has been directed toward automating this process. To do this, one needs to formulate the scientific process in a precise mathematical language. This paper outlines one such language. What is presented here is hardly
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The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source