Results 121 to 130 of about 7,548,819 (305)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

“If the funders said to me that I have to dress in orange, I would dress in orange”: findings from qualitative interviews on researchers’ experiences of public involvement

Research Involvement and Engagement
Background Public involvement is increasingly mandated in health and medical research in the UK. With a push for its implementation from major funding bodies over the past few decades, we aimed to understand its current role in research through the lens ...
Lili Gyopár, Kirsten Bell, Viveka Guzman, Habiba Haque, Amna Rida, Paapa Baffoe, Dave Varughese, Helen Ward   +7 more
doaj   +1 more source

Automating Logistics Operations: Qualitative Insights from Four European Sites

Logistics
Background: Automated vehicles are increasingly entering logistics operations, driven by factors like controllability, standardization, and reduced risk.
Guglielmo Papagni, Setareh Zafari, Johann Schrammel, Manfred Tscheligi   +3 more
doaj   +1 more source

Investing in the Bottom Line: The Value Case for Improving Human Experience in Healthcare [PDF]

Investment in human experience is imperative for healthcare organizations. It is a strategic focus that can lead to great benefits. Those that overlook experience, seeing it as “simply” about satisfaction or survey data, do so at great cost to their ...
Carlson, Brian, Carron, Jennifer, Wolf, Jason A, Oliver, Brant J, Bhalla, Vishal, Oehlert, Julie K, Dixon, Lanie   +6 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Evaluating Leadership Training for Managers in Healthcare: Focusing on Effective Communication

Journal of Healthcare Leadership
Laurel Ann Oetjen,1,2 Chad Connor,1 Brooke Werneburg,1,2 Sheila Stevens,1 Sunanda Kane,3 Richard Elias1,3 1Office of Experience Training, Education & Coaching, Mayo Clinic, Rochester, MN, USA; 2Mayo Clinic College of Medicine and Science, Mayo Clinic,
Oetjen LA, Connor C, Werneburg B, Stevens S, Kane S, Elias R   +5 more
doaj  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The UX Moment: A Weave Digital Panel, Part Two

Weave: Journal of Library User Experience, 2015
In mid-January 2015, Weave reached out to a number of librarians who are doing user experience work with the hope of instigating and documenting the conversation they might have with one another.
Matthew Reidsma, Pete Coco
doaj   +2 more sources

Embracing embodied movement in eating disorder recovery: matters arising from Bongiorno and Heaner (2025)

Journal of Eating Disorders
This Matters Arising builds upon Bongiorno and Heaner’s (2025) narrative review of resistance training in eating disorder recovery. The authors expand the discussion by situating resistance training within a wider spectrum of embodied movement practices,
James Downs, Hannah Hickinbotham, Eric Pothen   +2 more
doaj   +1 more source

TOURISM EXPERIENCES AS EXPERIENCE ECONOMY [PDF]

Economic and Social Development 45th International Scientific Conference on Economic and Social Development – XIX International Social Congress (ISC 2019) : Book of Proceedings, 2019
The development of tourist products based on experience as the key exchange value requires an interdisciplinary approach, which, with applied marketing activities and competitive positioning by means of identity affirmation, leads to the positioning of tourist offer from the aspect of the experience economy.
Dujmović, Mauro, Vitasović, Aljoša
openaire   +1 more source