Results 61 to 70 of about 11,712,389 (339)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Planning from Failure: Transforming a Waterfront through Experimentation in a Placemaking Living Lab

Urban Planning, 2021
This article assesses on what happens when planning by experiment becomes imperative for strategic city sites such as waterfronts due to the failure of other forms of centralised, top-down, or market-led planning.
Ramon Marrades, Philippa Collin, Michelle Catanzaro, Eveline Mussi   +3 more
doaj   +1 more source

Improving Lightweight Structural Tuff Concrete Composition Using Three-Factor Experimental Planning

Infrastructures
Research into lightweight structural concrete using volcanic tuff is of great importance to the construction industry. These materials have excellent thermal insulation properties, which helps improve the energy efficiency of buildings.
Yerlan Y. Khamza, Maratbek T. Zhuginissov, Erzhan I. Kuldeyev, Zhanar O. Zhumadilova, Ruslan E. Nurlybayev   +4 more
doaj   +1 more source

Size and form of plots for the culture of the Italian pumpkin in plastic greenhouse Tamanho e forma de parcelas para a cultura da abóbora italiana cultivada em estufa plástica

Scientia Agricola, 2004
Quality control is the guaranty that experimental error is kept under acceptable levels, and the definition of the proper size and form of experimental plots ensures acurate experimental planning.
Rodrigo Machado Mello, Alessandro Dal'Col Lúcio, Lindolfo Storck, Leandro Homrich Lorentz, Ricardo Howes Carpes, Alexandra Augusti Boligon   +5 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

THE IVESTIGATION OF LIQUID-MOVING SELF-FIRMING MIXTURE FOR STEEL CASTING FORMS IN ORDER TO OPTIMIZE ITS CONTENT

Advanced Engineering Research, 2010
The aim of the optimization of the liquid-moving self-firming mixture (LSM) content together with the regenerated sand for making steel shaped casting forms is discussed.
Y.A. ZINCHENKO
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Liquefaction experiment and analysis projects (LEAP): Summary of observations from the planning phase

Soil Dynamics and Earthquake Engineering, 2017
The LEAP international collaboratory is introduced and its key objectives and main accomplishments during the planning phase of the US-LEAP (LEAP-2015) are presented. The main theme of LEAP-2015 was lateral spreading of sloping liquefiable soils.
M. Manzari, Mohamed El Ghoraiby, B. Kutter, M. Zeghal, T. Abdoun, P. Arduino, R. Armstrong, M. Beaty, T. Carey, Yunmin Chen, Alborz Ghofrani, D. Gutierrez, Nithyagopal Goswami, S. Haigh, W. Hung, S. Iai, P. Kokkali, Chung-Jung Lee, S. Madabhushi, L. Mejia, M. Sharp, T. Tobita, K. Ueda, Yan-Guo Zhou, K. Ziotopoulou   +24 more
semanticscholar   +1 more source