Results 101 to 110 of about 9,547 (313)

High resolution computation of the aerodynamics and acoustics of blade vortex interaction [PDF]

, 2008
In the present work, high resolution CFD simulations have been performed on an idealised problem of the interaction of an independently generated vortex with a rotor blade, including a case where the vortex directly impacts on the blade.
Duraisamy, K., Thom, A.
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Aerodynamics of vortex ingestion for aero-engines [PDF]

, 2013
The potential impact of inlet flow distortion on the stability and performance of aircraft engines remains a key concern for engine-airframe integration. Current and future configurations, such as Unmanned Combat Air Vehicles (UCAVs), and possible civil
McLelland, Grant
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EMUs Pantograph Aerodynamics Experimental Research in Dropping Status under Strong Wind Condition

机车电传动, 2016
When EMUs run at a high speed, the pantograph would be affected by airflow and blown up in dropping status, which would result in catenary short-circuit fault. In order to evaluate the pantograph aerodynamics characteristics in dropping status and ensure
JIAO Wengen
doaj  

Compensation of motor torque asymmetry during the take-off phase of an X-tail unmanned aerial vehicle [PDF]

FME Transactions
The use of Unmanned Aerial Systems is expanding rapidly across civil and military domains, with sustained growth anticipated in the coming decades. The X-tail UAV configuration, characterized by the absence of ailerons and higher wing loading, offers ...
Milenković-Babić Miodrag D., Ostojić Branislav G., Ristić Nemanja Z., Dovatov Biljana Z., Antonić Vuk D., Damljanović Dijana B., Rašuo Boško P.   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Simulation of Tail Boom Vibrations Using Main Rotor-Fuselage Computational Fluid Dynamics (CFD)

Applied Sciences, 2017
In this work, fully-resolved rotor-fuselage interactional aerodynamics is used as the forcing term in a model based on the Euler-Bernoulli equation, aiming to simulate helicopter tail-boom vibration.
Andrey Batrakov, Alexander Kusyumov, Sergey Kusyumov, Sergey Mikhailov, George N. Barakos   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Aerodynamics of F1 car side mirror [PDF]

, 2007
This study investigates the aerodynamic performance of a Formula 1 carrear view side mirror when the location of its glass is varied inside its frame. Bothexperimental and computational studies have been carried out for a simplifiedtwo-dimensional model ...
Hu, Zhiwei W., Rind, Elad
core