Results 121 to 130 of about 8,671,015 (345)

Some dynamic problems of rotating windmill systems [PDF]

open access: yes
The basic whirl stability of a rotating windmill on a flexible tower is reviewed. Effects of unbalance, gravity force, gyroscopic moments, and aerodynamics are discussed.
Dugundji, J.
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

EXPERIMENTAL STUDIES ON AN AERODYNAMIC SEPARATOR

open access: yesNiva Povolzhya
The amount of grain production requires special attention from the workers of the agro-industrial complex. On the basis of Penza State Agrarian University, an aerodynamic separator was designed and developed, which is used to separate the grain material into fractions and to clean it from light impurities.
I.O. NOVIKOV, O.N. KUKHAREV
openaire   +1 more source

Experimental unsteady aerodynamics of conventional and supercritical airfoils [PDF]

open access: yes
Experimental data on the unsteady aerodynamics of oscillating airfoils in transonic flow are presented. Two 0.5 m-chord airfoil models - an NACA 64A010 and an NLR 7301 - were tested in the NASA-Ames 11 by 11 foot Transonic Wind Tunnel at Mach numbers to ...
Davis, S. S., Malcolm, G., N.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Numerical and Experimental Studies of Sail Aerodynamics

open access: yes, 2022
The purpose of this investigation was the determination of the aerodynamic performance of sails and gain knowledge of the phenomena involved in order to improve the aerody¬namic characteristics. In this research, the airflow around different sails in four scenarios was studied.
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Experimental and numerical investigation of aerodynamic damping

open access: yes, 2023
This thesis introduces a new aeromechanical test facility for axial compressor rotors called ACTIVE (Axial Compressor Test rig for the Investigation of blisk Vibrations with an active Excitation system). Thanks to the closed loop design, the test facility can be operated at variable pressure levels as well as at vacuum without changing the test setup ...
openaire   +2 more sources

Temporally and spatially resolved flow in a two-stage axial compressor. Part 2: Computational assessment [PDF]

open access: yes
Fluid dynamics of turbomachines are complicated due to aerodynamic interactions between rotors and stators. It is necessary to understand the aerodynamics associated with these interactions in order to design turbomachines that are both light and compact
Dring, Robert P.   +3 more
core   +1 more source

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