Results 131 to 140 of about 8,671,015 (345)
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Analytical Modeling of Shrouded Rotors in Hover with Experimental and Computational Validation
ActuatorsRotors have been utilized for aircraft propulsion since the dawn of aviation, but their performance can degrade significantly if not properly designed. This study focuses on developing an accurate design tool and model validation for shrouded rotors.
Abdallah Dayhoum +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Numerical and Experimental Characterization of a Coanda-Type Industrial Air Amplifier
Applied SciencesThe performance of an industrial air amplifier is assessed through experimental and numerical characterization, with a focus on examining the influence of various operating conditions (isolated, “blowing,” and “suction” modes) and direct geometric ...
Miguel Chávez-Módena +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Experimental Study of the Aerodynamics of Sail in Natural Wind
Polish Maritime Research, 2018 In order to evaluate the impacts of a motor vessel after installing wind sails, the aerodynamics of the sail should be accurately calculated. However most of the research on sails are based on stable wind instead of natural wind which is changing ...
Xiangming Zeng, Huawu Zhang
doaj +1 more source
Application of a panel method to wake-vortex/wing interaction and comparison with experimental data [PDF]
The ability of the Vortex Separation AEROdynamics (VSAERO) program to calculate aerodynamic loads on wings due to interaction with free vortices was studied.
Ross, James C., Smith, Brian E.
core +1 more source
Whirl and Stall Flutter Simulation Using CFD [PDF]
, 2017 This paper presents recent research on numerical methods for whirl and stall flutter using computational fluid dynamics. The method involves coupling of the HMB3 CFD solver of the University of Glasgow and a NASTRAN derived structural model. Based upon
Barakos, George N., Higgins, Ross J.
core
Checkpoint blockade and the stem‐like T cell trade‐off
Molecular Oncology, EarlyView.Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley +1 more source
Experimental Determination of Pitch Damping Coefficient Using Free Oscillation Method
AerospaceThis paper outlines an experimental investigation conducted at the INCAS trisonic wind tunnel, focusing on the determination of pitch damping coefficient. The model used for this investigation is the Basic Finner Model, a standard model for dynamic tests
Ionuț Bunescu +2 more
doaj +1 more source