Results 131 to 140 of about 9,547 (313)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Aerodynamic Aspects of the Longitudinal Motion of a High-Lift Aircraft Configuration with Circulation Control [PDF]
, 2013 The aim of sub-project C1 of the Collaborative Research Center/Sonderforschungsbereich 880 (SFB 880) is to investigate numerically the flight mechanical characteristics of an aircraft with circulation controlled high-lift devices from an aerodynamic ...
Keller, Dennis, Rudnik, Ralf
core
Predicting wind turbine blade loads using vorticity transport and RANS methodologies [PDF]
, 2009 Two computational methods, one based on the solution of the vorticity transport equa- tion, and a second based on the solution of the Reynolds-Averaged Navier-Stokes equa- tions, have been used to simulate the aerodynamic performance of a horizontal ...
Brown, R.E. +3 more
core +2 more sources
Analysis of Flow Field Structure Characteristics of Dual Impinging Jets at Different Velocities
AerospaceThe flow structure and unsteady evolution characteristics of dual impinging jets represent a flow problem of significant engineering importance in the aerospace field.
Yifan Zhao +5 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Fluid-structure interactions of anisotropic thin composite materials for application to sail aerodynamics of a yacht in waves [PDF]
, 2009 In recent years technological innovations has allowed large improvements to be made in sail design and construction. Sails and in particular kite-sails have application for sport, ships’ auxiliary propulsion and even power generation.
Chapelle, D. +3 more
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Design and Development of a 5-Channel Arduino-Based Data Acquisition System (ABDAS) for Experimental Aerodynamics Research. [PDF]
Sensors (Basel), 2018 Vidal-Pardo A, Pindado S.
europepmc +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source