Results 111 to 120 of about 9,547 (313)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Numerical and Experimental Studies of Sail Aerodynamics
, 2022 The purpose of this investigation was the determination of the aerodynamic performance of sails and gain knowledge of the phenomena involved in order to improve the aerody¬namic characteristics. In this research, the airflow around different sails in four scenarios was studied.
openaire +2 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Recent advances in numerical and experimental downwind sail aerodynamics [PDF]
, 2019 Over the past two decades, the numerical and experimental progresses made in the field of downwind sail aerodynamics have contributed to a new understanding of their behaviour and improved designs.
Viola, Ignazio Maria +5 more
core +1 more source
Analytical Modeling of Shrouded Rotors in Hover with Experimental and Computational Validation
ActuatorsRotors have been utilized for aircraft propulsion since the dawn of aviation, but their performance can degrade significantly if not properly designed. This study focuses on developing an accurate design tool and model validation for shrouded rotors.
Abdallah Dayhoum +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Experimental Aerodynamics [PDF]
, 2010 Experimental techniques in aerodynamics: Pressure, temperature and velocity measurement techniques. Steady and unsteady pressure measurements and various types of pressure probes and transducers, errors in pressure measurements.
Kurtuluş, Dilek Funda
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Numerical and Experimental Characterization of a Coanda-Type Industrial Air Amplifier
Applied SciencesThe performance of an industrial air amplifier is assessed through experimental and numerical characterization, with a focus on examining the influence of various operating conditions (isolated, “blowing,” and “suction” modes) and direct geometric ...
Miguel Chávez-Módena +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Multi-Objective Numerical Optimization Applied to Aircraft Design [PDF]
, 2008 Aircraft design is a very complex process because several disciplines are involved at the same time: aerodynamics, structures, performances, propulsion, costs. From this point of view, the real aircraft is a compromise between several requirements, often
Grasso, Francesco
core