Results 61 to 70 of about 6,121,043 (241)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Numerical study of the unsteady aerodynamics of helicopter rotor aerofoils

, 1999
A two-dimensional model of the aerodynamics of rotor blades in forward flight is proposed in which the motion of the blade is represented by periodical variations of the freestrearn velocity and incidence. A novel implicit methodology for the solution
Shaw, Scott
core   +3 more sources

Identification of roll damping coefficient using the free rotation method [PDF]

INCAS Bulletin
The free rotation method represents the simplest method for roll damping coefficient identification in experimental aerodynamics. To apply this method, it is necessary to spin the model to a desired angular velocity and then release the model to spin ...
Ionut BUNESCU, Mihai-Victor PRICOP, Mihaita-Gilbert STOICAN, Mihai-Vladut HOTHAZIE   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Upwind sail aerodynamics: A RANS numerical investigation validated with wind tunnel pressure measurements [PDF]

, 2012
The aerodynamics of a sailing yacht with different sail trims are presented, derived from simulations performed using computational fluid dynamics. A Reynolds-averaged Navier-Stokes approach was used to model sixteen sail trims first tested in a wind ...
VIOLA, Ignazio, Riotte, M., Viola, I. M.; id_orcid, RIOTTE, Matthieu, Bot, P., BOT, Patrick, VIOLA, I.M   +6 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Ground Effect Influence on UAV Propeller Thrust: Experimental and CFD Validation

Technologies
This work investigates the influence of ground effect on the performance of a UAV propeller through a combined experimental, analytical, and numerical approach.
Mădălin Dombrovschi, Gabriel-Petre Badea, Tiberius-Florian Frigioescu, Maria Căldărar, Daniel-Eugeniu Crunțeanu   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Experimental Hypersonic Aerodynamics and Advances in Aerospace Engineering [PDF]

فناوری در مهندسی هوافضا, 2017
Most space missions fall in the hypersonic reentry regime. There are several open questions and unknown phenomena in aerothermodynamics around vehicles at flow regimes exceeding Mach 4 due to its inherent complexities.
Shahed Malekipour, Mohammad Ebrahimi
doaj