Results 51 to 60 of about 5,875,132 (282)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Experimental Investigation of the Aerodynamics and Aeroelasticity of Flapping, Plunging and Pitching Wings

, 2012
This thesis concerns the experimental analysis of the aerodynamics and aeroelasticity of oscillating wings. It is divided into two sections, an investigation of wings undergoing imposed root flapping and pitching motion, such as seen in avian flight and ...
Norizham, Abdul Razak
core   +1 more source

Experimental and numerical investigation of aerodynamic damping

, 2023
This thesis introduces a new aeromechanical test facility for axial compressor rotors called ACTIVE (Axial Compressor Test rig for the Investigation of blisk Vibrations with an active Excitation system). Thanks to the closed loop design, the test facility can be operated at variable pressure levels as well as at vacuum without changing the test setup ...
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Flow Characterization Around a Mars Rover Model at Extremely Low Reynolds Number

Engineering Proceedings
This work presents an experimental aerodynamic study of a Mars rover model, aimed at characterizing its flow behavior under Martian environmental conditions. Due to the extremely low Reynolds numbers associated with Mars’ thin atmosphere, the experiments
Jaime Fernández-Antón, Rafael Bardera-Mora, Ángel Rodríguez-Sevillano, Juan Carlos Matías-García, Estela Barroso-Barderas   +4 more
doaj   +1 more source

Design, Development and Testing of Shape Shifting Wing Model

Aerospace, 2017
The design and development of morphing (shape shifting) aircraft wings—an innovative technology that has the potential to increase the aerodynamic efficiency and reduce noise signatures of aircrafts—was carried out.
Dean Ninian, Sam M. Dakka
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Numerical and Experimental Investigations of an Elasto-Flexible Membrane Wing at a Reynolds Number of 280,000

Aerospace, 2017
This work presents numerical and experimental investigations of an elasto-flexible membrane wing at a Reynolds number of 280,000. Such a concept has the capacity to adapt itself to the incoming flow offering a wider range of the flight envelope.
Julie Piquee, Christian Breitsamter
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source