Results 181 to 190 of about 170,172,984 (310)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Metformin Attenuates Behavioral Deficits and Oxidative Stress in a Preclinical Model of Autism. [PDF]

Dev Neurobiol
Freitas MC, Freitas RF, Vasconcelos IKM, Andrade IP, Pitombeira MHDS, Fontenele DR, Alves POF, Diógenes VS, Assreuy AMS, Aragão GF.   +9 more
europepmc   +1 more source

CONFERENCE ON THE EXPERIMENTAL ANALYSIS OF BEHAVIOR [PDF]

Journal of the Experimental Analysis of Behavior, 1959
openaire   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Generalization of the disruptive effects of alternative stimuli when combined with target stimuli in extinction

, 2017
Bland, Vikki, Bai, John, MIranda-Dukoski, L, Chan, CKJ, Podlesnik, CA   +4 more
core   +1 more source

Impact of bacterial exposure on the mechanical behavior of nickel-titanium open-coil springs. [PDF]

Biomater Investig Dent
Muñóz DPH, Balseca MA, Zapata MEV, Freitas KMS, Tualombo SWT.   +4 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Finite Element Analysis of the Flexural Performance of ECC-Concrete Composite Beams Reinforced with GFRP-Steel Composite Bars. [PDF]

Polymers (Basel)
Ling Y, Luo X, Xu S, Feng Z, Qin J, Zhong Y, Cai Y.   +6 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effects of Dietary <i>Melissa officinalis</i> Supplementation on Hematological, Neuroendocrine, and Behavioral Parameters in Weaned Piglets and in the Beginning of the Fattening Period. [PDF]

Life (Basel)
Petrova M, Veleva P, Ivanova S.
europepmc   +1 more source