Results 171 to 180 of about 1,391,396 (316)

Zoographics in the Journal of the Experimental Analysis of Behavior: Increasing inclusion of female animals. [PDF]

J Exp Anal Behav
Odum AL, Callister KT, Willis-Moore ME, Da Silva DS, Legaspi DN, Scribner LN, Hannah JN.   +6 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Perceptual outcomes as reinforcers

, 2003
The paucity of basic behavioral research with humans was highlighted almost 40 years ago (Findley, 1966). A recent search of the basic behavioral research journals by the present authors indicated that this situation remains, with only approximately 15 ...
McEwan, James S.A., Sumpter, Catherine E.   +1 more
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Laboratory lore and research practices in the experimental analysis of human behavior: Subject selection

, 1988
Discusses data on S selection processes obtained from a literature survey and 52 members of the Association for Behavior Analysis. Choice of S samples is discussed in terms of marker variables, including age, gender, and diagnostic category, and S ...
Todd, James T., Johnson, Lisa M., Morris, Edward K., Higgins, Stephen T.   +3 more
core  

THE EXPERIMENTAL ANALYSIS OF HUMAN BEHAVIOR [PDF]

Journal of the Experimental Analysis of Behavior, 1990
Douglas J. Navarick, Daniel J. Bernstein, Edmund Fantino   +2 more
openaire   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Relating different perspectives on how outcomes of behavior influence behavior

Many researchers have tackled the question of how behavior is influenced by its outcomes. Some have adopted a nonmechanistic (functional) perspective that attempts to describe the influence of outcomes on behavior.
De Houwer, JanPP058010015698410000-0003-0488-5224F64655F6-F0ED-11E1-A9DE-61C894A0A6B4, Cummins, JamiePP050001715064078020027968680000-0002-9729-4900100CE610-F4C8-11E7-A048-ADCA11A95AF2, Hughes, Sean JosephUGent0001506757568020014080519786135540250000-0001-7689-427266192C90-6CC3-11E2-9EA0-5E6B10BDE39D, Boddez, YannickPP058020025258740000-0002-8067-59697F4BCE40-E8D2-11E6-B221-4557AE28A064, Finn, MartinPP050001511789448020021912260000-0002-5035-979758B010B0-649A-11E5-9CDC-0298B5D1D7B1   +4 more
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source