Results 131 to 140 of about 7,418 (172)
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The Effect of BCG on Experimental Cutaneous Leishmaniasis in Mice
The Journal of Immunology, 1977Abstract The effect of administration of live Bacillus Calmette-Guerin (BCG), a nonspecific immunostimulant, on the course of experimental cutaneous leishmaniasis in mice was investigated. BALB/c mice were injected in the footpad with Leishmania tropica, NIH S-strain; in mice that were not pretreated with BCG this produced a reproducible
Weintraub, J, Weinbaum, F I
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Aminosidine ointments for the treatment of experimental cutaneous leishmaniasis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994A 15% aminosidine sulphate (AS)/10% urea/white soft paraffin (WSP) ointment cured all Leishmania major lesions on Balb/C mice following topical application for 10 d. Some relapses were observed 10 weeks after treatment. AS alone in WSP ointment was also highly effective.
R A, Neal +3 more
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Leishmania major: Activity of tamoxifen against experimental cutaneous leishmaniasis
Experimental Parasitology, 2011Leishmaniasis is a family of diseases caused by protozoan parasites of the genus Leishmania. Various Leishmania species can cause human infection, producing a spectrum of clinical manifestations. The current treatments are unsatisfactory, and in absence of a vaccine, there is an urgent need for effective drugs to replace/supplement those currently in ...
Maha Eissa, Eglal I Amer
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The American Journal of Tropical Medicine and Hygiene, 1982
Abstract Leishmania tropica infections in mice provide models for the study of non-healing leishmanial infections similar to diffuse cutaneous leishmaniasis (DCL) in man. BALB/c mice infected with L. tropica developed large non-healing primary lesions as well as multiple metastatic lesions on the feet, face and ears.
P A, Scott, J P, Farrell
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Abstract Leishmania tropica infections in mice provide models for the study of non-healing leishmanial infections similar to diffuse cutaneous leishmaniasis (DCL) in man. BALB/c mice infected with L. tropica developed large non-healing primary lesions as well as multiple metastatic lesions on the feet, face and ears.
P A, Scott, J P, Farrell
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An Experimental Model of the Production of Metastases in Murine Cutaneous Leishmaniasis
The Journal of Parasitology, 1994An experimental investigation into the influence of artificially induced trauma in the production of leishmanial metastatic lesions and into the possible role played by Leishmania-reactive T cell populations in the metastatic process was carried out. Trauma was induced by incising a small cut into the shaved rump of Leishmania amazonensis-infected BALB/
A L, Bertho +2 more
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The Immunology of Cutaneous Leishmaniasis: Experimental Infections and Human Disease
World Class Parasites, 2002Cutaneous leishmaniasis (CL) is a term used to describe a group of diseases caused by multiple species of parasites within the genus Leishmania. Most cases of cutaneous leishmaniasis will spontaneously heal without external intervention, although the severity of disease and time course for healing may vary enormously depending on the species of ...
Jay P Farrell, Farrell Jay P
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Cell-mediated immunity in experimental cutaneous leishmaniasis
Parasitology Today, 1986Forms of cutaneous leishmaniasis are caused by Leishmania major, L. tropica, L. mexicana, L. amazonensis and L. panamensis. Like all leishmanial species, these are obligate intracellular parasites of the mononuclear phagocyte system, with a restricted range of vertebrate hosts including humans, dogs, rodents and arboreal animals.
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Immunopathology of experimental cutaneous leishmaniasis.
The American journal of pathology, 1984Relatively susceptible BALB/c and relatively resistant A/J mice were infected subcutaneously in the right hind footpad with promastigotes of Leishmania mexicana amazonensis. A large localized lesion developed within 2 months after infection in the BALB/c mice, while A/J mice exhibited a small discrete fibrotic nodule.
Andrade, Z A +3 more
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Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3
European Journal of Immunology, 1988AbstractPrevious studies from our laboratory have shown that some in vitro maintained Leish‐mania major‐specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin 3 (IL 3) and granulocyte ...
Feng ZY +6 more
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Experimental murine infection with the diffuse cutaneous leishmaniasis strain, Isabel
Annals of Tropical Medicine & Parasitology, 1987Infection with the Isabel strain of Leishmania has been followed in several inbred strains of mice over an extended period. The mouse strains segregate into three major types with respect to susceptibility to infection: BALB/c, BALB.B and SWR/J are susceptible; DBA/1J is intermediate; and C57BL/6, C57BL/10, DBA/2J and B10.D2 are resistant.
B A, Shaw, J B, Grayson, E A, Petersen
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