Cytokine interactions in experimental cutaneous leishmaniasis.
Behring Institute Mitteilungen, 1991Destruction of intracellularly living Leishmania major amastigotes is achieved by activated macrophages. In this report, we have investigated the contribution of IL-4, TNF-alpha and IFN-gamma to the induction of antileishmanial macrophage activation.
W, Solbach +3 more
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Neuropeptide Y concentrations in experimental Leishmania major cutaneous leishmaniasis
NeuroReport, 1998Neuropeptide Y (NPY) concentrations were investigated by radioimmunoassay and immunohistochemistry in a murine model of cutaneous leishmaniasis, using a susceptible (BALB/c) and a resistant (C57BL/6) mouse strain. The analyses were performed on the skin, secondary lymphoid organs and dorsal root ganglia (DRG) at 1, 3, 6 and 9 weeks postinfection.
A A, Ahmed +3 more
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Antigen presentation by epidermal langerhans cells in experimental cutaneous leishmaniasis
Parasite Immunology, 1994SUMMARYCutaneous leishmaniasis is a disease induced by intradermal injection of leishmania promastigotes. Since the first cells the parasite encounters are those of the skin, the involvement of this organ in the early immune response might be relevant to the outcome of the disease. In this study we examined the ability of epidermal langerhans cells (LC)
O, Axelrod, S, Klaus, S, Frankenburg
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A new view on cutaneous dendritic cell subsets in experimental leishmaniasis
Medical Microbiology and Immunology, 2006Because of their anatomical distribution epidermal Langerhans cells (LCs) are discussed to be crucial for antigen uptake and subsequent presentation to naïve T cells in skin-draining lymph nodes. The use of LC-specific markers like Langerin or knock-in mice expressing green fluorescent protein under the control of the Langerin promotor now facilitates ...
Uwe, Ritter, Anke, Osterloh
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Nitric oxide and cellular immunity in experimental cutaneous leishmaniasis.
Clinical and experimental dermatology, 2003We examined the local and systemic production of nitric oxide (NO) and the pattern of cytokine during the course of Leishmania mexicana infection in susceptible BALB/c and resistant C57BL/6 mice. NO derivatives were measured in serum, and the expression of inducible nitric oxide synthase (iNOS), interferon (IFN-gamma), interleukin (IL-4) and epidermal ...
N L, Díaz +5 more
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[Experimental models of cutaneous leishmaniasis in laboratory animals].
Parazitologiia, 1986A survey of literature on modelling cutaneous leishmaniasis of man (common and metastatic) on some lines of mice, guinea pigs, golden hamsters infected with different species of Leishmania is given. Merits and demerits of each described model are pointed out.
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Modulation of Cell-Mediated Immunity in Experimental Cutaneous Leishmaniasis
1989It is now generally accepted that cell-mediated immunity plays a causal role in acquired resistance to leishmaniasis. This is based on an impressive range of clinical and experimental evidence (Table 1). Patients with active visceral leishmaniasis failed to respond to L.
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Treatment of experimental cutaneous leishmaniasis by liposome-entrapped Pentostam
Acta tropica, 1980R R, New, M L, Chance
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Subsets of specific T cells and experimental cutaneous leishmaniasis
Annales de l'Institut Pasteur / Immunologie, 1987Louis JA +8 more
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South American Cutaneous Leishmaniasis in Experimental Animals
The Journal of Parasitology, 1942H. S. Fuller, Q. M. Geiman
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