Results 171 to 180 of about 8,397 (218)
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Leishmania major: Activity of tamoxifen against experimental cutaneous leishmaniasis
Experimental Parasitology, 2011Leishmaniasis is a family of diseases caused by protozoan parasites of the genus Leishmania. Various Leishmania species can cause human infection, producing a spectrum of clinical manifestations. The current treatments are unsatisfactory, and in absence of a vaccine, there is an urgent need for effective drugs to replace/supplement those currently in ...
Maha M Eissa, Eglal I Amer
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The Immunology of Cutaneous Leishmaniasis: Experimental Infections and Human Disease
World Class Parasites, 2002Cutaneous leishmaniasis (CL) is a term used to describe a group of diseases caused by multiple species of parasites within the genus Leishmania. Most cases of cutaneous leishmaniasis will spontaneously heal without external intervention, although the severity of disease and time course for healing may vary enormously depending on the species of ...
Farrell Jay P
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Experimental cutaneous leishmaniasis
Acta Tropica, 1997Fernando Tobias Silveira +2 more
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Immunobiology of experimental cutaneous leishmaniasis
Parasitology Today, 1995The study of the murine model of infection with Leishmania major is providing important insights into the understanding of the complex interactions between the host and intracellular pathogens. Using this model system, basic research is actively leading to the identification of host factors promoting or circumventing the development of immunity to L ...
G, Milon, G, Del Giudice, J A, Louis
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Natural Killer Activity in Experimental Cutaneous Leishmaniasis
International Archives of Allergy and Applied Immunology, 2009Studies were performed to determine the role of natural killer (NK) cell cytotoxicity in experimental cutaneous leishmaniasis. Analysis of a possible correlation between in vitro NK cell activity and in vivo susceptibility to Leishmania mexicana infection showed that there is no relationship between the degree of NK reactivity to YAC-1 lymphoma cells ...
F, Merino, I, Cruz
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The Effect of BCG on Experimental Cutaneous Leishmaniasis in Mice
The Journal of Immunology, 1977Abstract The effect of administration of live Bacillus Calmette-Guerin (BCG), a nonspecific immunostimulant, on the course of experimental cutaneous leishmaniasis in mice was investigated. BALB/c mice were injected in the footpad with Leishmania tropica, NIH S-strain; in mice that were not pretreated with BCG this produced a reproducible
Weintraub, J, Weinbaum, F I
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Aminosidine ointments for the treatment of experimental cutaneous leishmaniasis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1994A 15% aminosidine sulphate (AS)/10% urea/white soft paraffin (WSP) ointment cured all Leishmania major lesions on Balb/C mice following topical application for 10 d. Some relapses were observed 10 weeks after treatment. AS alone in WSP ointment was also highly effective.
R A, Neal +3 more
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The American Journal of Tropical Medicine and Hygiene, 1982
Abstract Leishmania tropica infections in mice provide models for the study of non-healing leishmanial infections similar to diffuse cutaneous leishmaniasis (DCL) in man. BALB/c mice infected with L. tropica developed large non-healing primary lesions as well as multiple metastatic lesions on the feet, face and ears.
P A, Scott, J P, Farrell
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Abstract Leishmania tropica infections in mice provide models for the study of non-healing leishmanial infections similar to diffuse cutaneous leishmaniasis (DCL) in man. BALB/c mice infected with L. tropica developed large non-healing primary lesions as well as multiple metastatic lesions on the feet, face and ears.
P A, Scott, J P, Farrell
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Efficacy of topical Miltefosine formulations in an experimental model of cutaneous leishmaniasis
Drug Delivery and Translational Research, 2021Cutaneous leishmaniasis (CL) is a neglected tropical disease endemic in ~ 90 countries, with an increasing incidence. Presently available pharmacotherapy implies the systemic administration of moderately/very toxic drugs. Miltefosine (Milt) is the only FDA-approved drug to treat CL via the oral route (Impavido®). It produces side effects; in particular,
Ma. Florencia Peralta +7 more
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An Experimental Model of the Production of Metastases in Murine Cutaneous Leishmaniasis
The Journal of Parasitology, 1994An experimental investigation into the influence of artificially induced trauma in the production of leishmanial metastatic lesions and into the possible role played by Leishmania-reactive T cell populations in the metastatic process was carried out. Trauma was induced by incising a small cut into the shaved rump of Leishmania amazonensis-infected BALB/
A L, Bertho +2 more
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