Results 181 to 190 of about 8,397 (218)
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Cell-mediated immunity in experimental cutaneous leishmaniasis
Parasitology Today, 1986Forms of cutaneous leishmaniasis are caused by Leishmania major, L. tropica, L. mexicana, L. amazonensis and L. panamensis. Like all leishmanial species, these are obligate intracellular parasites of the mononuclear phagocyte system, with a restricted range of vertebrate hosts including humans, dogs, rodents and arboreal animals.
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Immunopathology of experimental cutaneous leishmaniasis.
The American journal of pathology, 1984Relatively susceptible BALB/c and relatively resistant A/J mice were infected subcutaneously in the right hind footpad with promastigotes of Leishmania mexicana amazonensis. A large localized lesion developed within 2 months after infection in the BALB/c mice, while A/J mice exhibited a small discrete fibrotic nodule.
Andrade, Z A +3 more
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Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3
European Journal of Immunology, 1988AbstractPrevious studies from our laboratory have shown that some in vitro maintained Leish‐mania major‐specific L3T4+ T cells were capable of exacerbating cutaneous leishmaniasis after adoptive transfer to normal syngeneic mice. Results presented in this report show that these cells released substantial amounts of interleukin 3 (IL 3) and granulocyte ...
Feng ZY +6 more
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Experimental murine infection with the diffuse cutaneous leishmaniasis strain, Isabel
Annals of Tropical Medicine & Parasitology, 1987Infection with the Isabel strain of Leishmania has been followed in several inbred strains of mice over an extended period. The mouse strains segregate into three major types with respect to susceptibility to infection: BALB/c, BALB.B and SWR/J are susceptible; DBA/1J is intermediate; and C57BL/6, C57BL/10, DBA/2J and B10.D2 are resistant.
B A, Shaw, J B, Grayson, E A, Petersen
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Cytokine interactions in experimental cutaneous leishmaniasis.
Behring Institute Mitteilungen, 1991Destruction of intracellularly living Leishmania major amastigotes is achieved by activated macrophages. In this report, we have investigated the contribution of IL-4, TNF-alpha and IFN-gamma to the induction of antileishmanial macrophage activation.
W, Solbach +3 more
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Neuropeptide Y concentrations in experimental Leishmania major cutaneous leishmaniasis
NeuroReport, 1998Neuropeptide Y (NPY) concentrations were investigated by radioimmunoassay and immunohistochemistry in a murine model of cutaneous leishmaniasis, using a susceptible (BALB/c) and a resistant (C57BL/6) mouse strain. The analyses were performed on the skin, secondary lymphoid organs and dorsal root ganglia (DRG) at 1, 3, 6 and 9 weeks postinfection.
A A, Ahmed +3 more
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Antigen presentation by epidermal langerhans cells in experimental cutaneous leishmaniasis
Parasite Immunology, 1994SUMMARYCutaneous leishmaniasis is a disease induced by intradermal injection of leishmania promastigotes. Since the first cells the parasite encounters are those of the skin, the involvement of this organ in the early immune response might be relevant to the outcome of the disease. In this study we examined the ability of epidermal langerhans cells (LC)
O, Axelrod, S, Klaus, S, Frankenburg
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A new view on cutaneous dendritic cell subsets in experimental leishmaniasis
Medical Microbiology and Immunology, 2006Because of their anatomical distribution epidermal Langerhans cells (LCs) are discussed to be crucial for antigen uptake and subsequent presentation to naïve T cells in skin-draining lymph nodes. The use of LC-specific markers like Langerin or knock-in mice expressing green fluorescent protein under the control of the Langerin promotor now facilitates ...
Uwe, Ritter, Anke, Osterloh
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Nitric oxide and cellular immunity in experimental cutaneous leishmaniasis.
Clinical and experimental dermatology, 2003We examined the local and systemic production of nitric oxide (NO) and the pattern of cytokine during the course of Leishmania mexicana infection in susceptible BALB/c and resistant C57BL/6 mice. NO derivatives were measured in serum, and the expression of inducible nitric oxide synthase (iNOS), interferon (IFN-gamma), interleukin (IL-4) and epidermal ...
N L, Díaz +5 more
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[Experimental models of cutaneous leishmaniasis in laboratory animals].
Parazitologiia, 1986A survey of literature on modelling cutaneous leishmaniasis of man (common and metastatic) on some lines of mice, guinea pigs, golden hamsters infected with different species of Leishmania is given. Merits and demerits of each described model are pointed out.
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