Results 101 to 110 of about 23,725,775 (352)

Study designs: Part 4 – Interventional studies

Perspectives in Clinical Research, 2019
In the fourth piece of this series on research study designs, we look at interventional studies (clinical trials). These studies differ from observational studies in that the investigator decides whether or not a participant will receive the exposure (or
Rakesh Aggarwal, Priya Ranganathan
doaj   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

FEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel, A. F. Volker Wagner, R. Gary Sawers   +2 more
wiley   +1 more source

Optimal plot size in the evaluation of papaya scions: proposal and comparison of methods

Revista Ceres
Evaluating the quality of scions is extremely important and it can be done by characteristics of shoots and roots. This experiment evaluated height of the aerial part, stem diameter, number of leaves, petiole length and length of roots of papaya ...
Humberto Felipe Celanti, Edilson Romais Schmildt, Omar Schmildt, Rodrigo Sobreira Alexandre, Laercio Francisco Cattaneo   +4 more
doaj   +1 more source

Experimental design for single-cell RNA sequencing

Briefings in Functional Genomics, 2017
Single-cell RNA sequencing (scRNA-seq) has opened new avenues for the characterization of heterogeneity in a large variety of cellular systems. As this is a relatively new technique, the field is fast evolving.
J. Baran-Gale, Tamir Chandra, K. Kirschner   +2 more
semanticscholar   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Contest Design: An Experimental Investigation [PDF]

This paper experimentally compares the performance of four simultaneous lottery contests: a grand contest, two multiple prize settings (equal and unequal prizes), and a contest which consists of two subcontests.
Roman M. Sheremeta
core  

Adaptive Experimental Design Using the Propensity Score [PDF]

Many social experiments are run in multiple waves, or are replications of earlier social experiments. In principle, the sampling design can be modified in later stages or replications to allow for more efficient estimation of causal effects.
Dean Karlan, Jinyong Hahn, Keisuke Hirano   +2 more
core   +3 more sources

Assessment of Stability and Adaptation Patterns of White Sugar Yield from Sugar Beet Cultivars in Temperate Climate Environments

Agronomy, 2019
The yield and yield quality of sugar from the sugar beet (Beta vulgaris L.) and are determined by genotype, environment and crop management. This study was aimed at analyzing the stability of white sugar yield and the adaptation of cultivars based on 36 ...
Marcin Studnicki, Tomasz Lenartowicz, Kinga Noras, Elżbieta Wójcik-Gront, Zdzisław Wyszyński   +4 more
doaj   +1 more source

Planning experiments: Updated guidance on experimental design and analysis and their reporting III

British Journal of Pharmacology, 2022
M. Curtis, Stephen P A Alexander, G. Cirino, Christopher H George, D. Kendall, P. Insel, A. Izzo, Yong Ji, R. Panettieri, H. Patel, C. Sobey, S. Stanford, P. Stanley, Barbara Stefanska, Gary J Stephens, Mauro M Teixeira, N. Vergnolle, A. Ahluwalia   +17 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source