Results 81 to 90 of about 6,611,994 (284)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Optimal plot size in the evaluation of papaya scions: proposal and comparison of methods

Revista Ceres
Evaluating the quality of scions is extremely important and it can be done by characteristics of shoots and roots. This experiment evaluated height of the aerial part, stem diameter, number of leaves, petiole length and length of roots of papaya ...
Humberto Felipe Celanti, Edilson Romais Schmildt, Omar Schmildt, Rodrigo Sobreira Alexandre, Laercio Francisco Cattaneo   +4 more
doaj   +1 more source

Variance heterogeneity in experimental design [PDF]

Statistical ...
Kleijnen, J.P.C.
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Study designs: Part 4 – Interventional studies

Perspectives in Clinical Research, 2019
In the fourth piece of this series on research study designs, we look at interventional studies (clinical trials). These studies differ from observational studies in that the investigator decides whether or not a participant will receive the exposure (or
Rakesh Aggarwal, Priya Ranganathan
doaj   +1 more source

A Unified Checklist for Observational and Experimental Research in Software Engineering (Version 1) [PDF]

, 2012
Current checklists for empirical software engineering cover either experimental research or case study research but ignore the many commonalities that exist across all kinds of empirical research.
Wieringa, Roel
core   +2 more sources

Design, Fabrication, and Experimental Demonstration of Junction Surface Ion Traps

, 2011
We present the design, fabrication, and experimental implementation of surface ion traps with Y-shaped junctions. The traps are designed to minimize the pseudopotential variations in the junction region at the symmetric intersection of three linear ...
Allcock D T C, Amini J M, Amini J M Britton J Leibfried D Wineland D J, Britton J, Brownnutt M, C Highstrete, C Tigges, Chiaverini J, D L Moehring, D Stick, Daniilidis N, Harlander M, Hellwig M, Herskind P F, Hughes M D Lekitsch B Broersma J A Hensinger W K, K M Fortier, Kumph M Brownnutt M Blatt R, Leibrandt D R, M G Blain, Ospelkaus C, R Haltli, Rowe M A, Stick D, Wineland D J   +23 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optical Time-Frequency Packing: Principles, Design, Implementation, and Experimental Demonstration

, 2015
Time-frequency packing (TFP) transmission provides the highest achievable spectral efficiency with a constrained symbol alphabet and detector complexity.
Cavaliere, Fabio, Colavolpe, Giulio, Foggi, Tommaso, Forestieri, Enrico, Fresi, Francesco, Meloni, Gianluca, Potì, Luca, Prati, Giancarlo, Sabella, Roberto, Secondini, Marco   +9 more
core   +1 more source