Results 61 to 70 of about 13,988,307 (212)
, 1973 The first issue of the Journal of Multivariate Experimental Personality and Clinical Psychology edited by G.R. Pierson. Editorial policy board: Raymond B. Cattell, Hans J. Eysenck, Joy P. Guilford and Paul E. Meehl.Digitized and published in SOAR:Shocker
Western Institute of Multivariate Experimental Psychology
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Creative Industries Innovation Centre Case Study - e2 experimental design 2011.pdf
, 2015 PDF version of an article written for the creativeinnovation website, part of a series of articles showcasing the experience and knowledge of companies in the creative industries in Australia.
Creative Industries Innovation Centre
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Surfing for Inspiration: digital inspirational material in design practice [PDF]
, 2018 Over the last decade, many new opportunities have emerged to support creativity and problem-solving in design by finding inspirational materials via the Internet.
Laszlo, Magda +8 more
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Modeling the early stages of a user-centered process in architectural design through adaptation of the methodologies of New Product Design [PDF]
, 2009 In order to reach a degree of quality in architectural buildings that is likely to lead to user satisfaction, architectural design relies on integrating user-related information even before generation of building concepts.
BOUCHARD, Carole +2 more
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, 1975 The third issue of the Journal of Multivariate Experimental Personality and Clinical Psychology edited by G.R. Pierson. Editorial policy board: R.B. Cattell, H.J. Eysenck, J.P. Guilford and P.E.
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Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source