Results 71 to 80 of about 2,979,229 (315)

An Experimental Framework for Designing a Parametric Design Course

open access: yes, 2021
Architectural forms, architectural knowledge, design process, and design thinking are all changing with the use of computer-aided design programmes, and even traditional university architecture departments now wish to teach these programmes.
Agirbas, Asli
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transitions, social practices and design : notes from a transdisciplinary research project

open access: yes, 2014
There is currently great interest in the idea of transitions to help bring on more sustainable societies and cultures. This is demonstrated by community led projects like Transition Towns, and government sponsored reports such as the German Advisory ...
Fam, Dena, Mellick Lopes, Abby (R11243)
core  

Triterpenes in breast cancer: a systematic review of preclinical evidence in rodents

open access: yesFrontiers in Pharmacology
IntroductionBreast cancer poses a significant health problem for women worldwide due to late-stage diagnosis, toxicity of standard therapy and drug resistance.
Alexandra Prodea   +14 more
doaj   +1 more source

New Glass Design Approaches Developed During an Experimental Student Workshop

open access: yesChallenging Glass Conference Proceedings, 2010
During two semesters the ILEK (Institute for Lightweight Structures and Conceptual Design) held an explorative student workshop focusing on new glass design possibilities.
Kerstin Puller   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Creative Industries Innovation Centre Case Study - e2 experimental design 2011.pdf

open access: yes, 2015
PDF version of an article written for the creativeinnovation website, part of a series of articles showcasing the experience and knowledge of companies in the creative industries in Australia.
Creative Industries Innovation Centre
core  

Assessment of Stability and Adaptation Patterns of White Sugar Yield from Sugar Beet Cultivars in Temperate Climate Environments

open access: yesAgronomy, 2019
The yield and yield quality of sugar from the sugar beet (Beta vulgaris L.) and are determined by genotype, environment and crop management. This study was aimed at analyzing the stability of white sugar yield and the adaptation of cultivars based on 36 ...
Marcin Studnicki   +4 more
doaj   +1 more source

Optimum Experimental Designs

open access: yesJournal of the Royal Statistical Society Series B: Statistical Methodology, 1959
Summary After some introductory remarks, we discuss certain basic considerations such as the nonoptimality of the classical symmetric (balanced) designs for hypothesis testing, the optimality of designs invariant under an appropriate group of transformations, etc. In section 3 we discuss complete classes of designs, while in section 4 we
openaire   +3 more sources

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