Results 131 to 140 of about 2,979,229 (315)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Entangled in the design of a relational materiality : Beyond smart textiles

Nowadays, ethics and care for the environment have shifted paradigms in smart textile design towards responsible energy use and preservation of natural resources.
Lastusaari, Mika, Lewis, Erin, Ladekarl, Inger Marie, Vapaavuori, Jaana, Madani, Zahra, Nyberg, Mikael, Lawrynowicz, Alicja, Kramer Pedersen, Lena, Madani, Zahraalsadat, Mohan, Mithila, Harsaae, Malene, Miettunen, Kati, Landin, Hanna, Rödby, Kristian, Worbin, Linda, Bang, Anne Louise, Latusaari, Mika, Pedersen, Lena, Silva, Pedro, Vapaavouri, Jaana, Dumitrescu, Delia, Vaara, Maija   +21 more
core   +1 more source

Experimental Designs [PDF]

The Behavior Analyst, 1990
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Design of a Virtual Articulator for the Simulation and Analysis of Mandibular Movements in Dental CAD/CAM [PDF]

, 2009
Organised by: Cranfield UniversityThis paper presents a research project aiming at designing a Virtual Articulator in order to simulate and analyze mandibular movements of the human jaw.
Muniozguren, J., Solaberrieta, E., Arias, A., Etxaniz, O., Minguez, R.   +4 more
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Experimental Design Approach to Evaluating Factors for Enhanced Cork Mass Insulation

Журнал інженерних наук
This research examines the mechanical properties of cork, explicitly focusing on enhancing its mass insulation characteristics by calculating the apparent diffusion coefficient.
Kermezli T., Announ M., Ladeg S., Douani M.   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Original Research: Descriptive or Analytical, Either-Or or Both-And?

Philippine Journal of Otolaryngology Head and Neck Surgery
descriptive (adj.) “serving or aiming to describe,” 1751, from Late Latin descriptivus, from descript-, past-participle stem of describere “to write down, copy; sketch, represent,” from de “down” (see de-) + scribere “to write” (from PIE root *skribh- “
José Florencio Lapeña
doaj   +1 more source