Results 201 to 210 of about 2,979,229 (315)

Design and Analysis of Monte Carlo Experiments

monte carlo experiments;simulation models;mathematical analysis;sensitivity analysis;experimental ...
Kleijnen, J.P.C.
core  

MicroAge mission: experimental design and hardware for a bespoke culture system supporting tissue-engineered skeletal muscle. [PDF]

NPJ Microgravity
Jones SW, Shigdar S, Temple J, Tollitt B, Janvier A, Mutter F, Henstock JR, Ohana J, Turner DA, McArdle C, Neri G, Blackler W, Olentsenko G, Hoettges KF, McArdle A, Jackson MJ.   +15 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Experimental design and control methods for dose rate optimization in a synchrotron-based proton therapy beamline. [PDF]

Precis Radiat Oncol
Tang J, Liu D, Mathew J, Campelo S, Bronk L, Taylor P, Li Y, Guan F.   +7 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Evaluation and Optimization of Azithromycin Removal by Raw and Alkali-Modified Peanut Shells Using Taguchi-Based Experimental Design Approach. [PDF]

Water Environ Res
Asad R, Hussain G, Usman M, Aurangzeb S, Afzal S, Fouad Y, Masood MI, Abbas N.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

"Transforming Pain": Evaluation of a Multicomponent Workshop for the Treatment of Chronic Pain-A Quasi-Experimental Design with Control Group. [PDF]

Healthcare (Basel)
Ruiz-Romero MV, Gómez-Hernández MB, Saz AP, Martínez-Monrobé MB, Gutiérrez-Fernández N, Arroyo-Rodríguez A, Garrido-Alfaro RA, López-Tarrida ÁC, Canal-Diez N, Guerra-Martín MD, Pereira-Delgado C.   +10 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effectiveness of a 5G Local Area Network-Based Digital Microscopy Interactive System: Quasi-Experimental Design. [PDF]

JMIR Med Educ
Xu J, Sha J, Jia S, Li J, Xu L, Shao Z.
europepmc   +1 more source