Application of Design Simulation and Experimental Design Methodologies to the Study of Coronary Stent Designs [PDF]
Computer-Aided Design and Applications, 2012 AbstractDesign Simulation and Experimental Design are widely used techniques in engineering design studies. Design simulation is useful in the virtual testing of new designs without having to spend resources on creating actual prototypes. Experimental Design is useful in analyzing relationships between various parameters of a design and their impact on
Jared May, Nilesh N. Joshi, Rajeev Nair
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Experimental Design and Validation of an Accelerated Random Vibration Fatigue Testing Methodology
Shock and Vibration, 2015 Novel accelerated random vibration fatigue test methodology and strategy are proposed, which can generate a design of the experimental test plan significantly reducing the test time and the sample size.
Yu Jiang +3 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Modeling the early stages of a user-centered process in architectural design through adaptation of the methodologies of New Product Design [PDF]
, 2009 In order to reach a degree of quality in architectural buildings that is likely to lead to user satisfaction, architectural design relies on integrating user-related information even before generation of building concepts.
BOUCHARD, Carole +2 more
core
A rigorous evaluation of crossover and mutation in genetic programming [PDF]
, 2009 The role of crossover and mutation in Genetic Programming (GP) has been the subject of much debate since the emergence of the field. In this paper, we contribute new empirical evidence to this argument using a rigorous and principled experimental method ...
David R. White +3 more
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Design Methodology and Experimental Verification of a Novel Orifice Plate Rectifier
FluidsOptimizing the rectification and pressure loss controlled by the aperture structure is challenging, with particular attention paid to the problem of precisely modeling the rectification process of multilayer wire mesh in pulse tube cryocoolers. This work
Zhe Li +5 more
doaj +1 more source
HIGH HYDROSTATIC PRESSURE EXTRACTION OF ANTIOXIDANTS FROM MORINDA CITRIFOLIA FRUIT – PROCESS PARAMETERS OPTIMIZATION [PDF]
Journal of Engineering Science and Technology, 2006 A modified version of high hydrostatic pressure extraction has been performed for extraction of antioxidants from M. citrifolia fruit at 5, 15, 25 bar and temperature 30° to 70°C for time duration 1, 2, 4 and 6 hours.
PRAVEEN KUMAR +3 more
doaj
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
A Comparison of Design Methodologies for Journal Bearings under Pulsatile Loads
, 2011 The paper expands the work by Kinnear and Weston[1] on squeeze film bearing design to the general case and compares the revised methodology with classical bearing design[2,3,4] and hybrid bearing design[5].
Weston, W. +8 more
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