Results 51 to 60 of about 2,245,571 (350)

Peptides binding cocaine: A strategy to design biomimetic receptors [PDF]

, 2013
A computational methodology for designing and rationalizing the selection of small peptides as biomimetic receptors for cocaine is proposed. The method started by searching and filtering proteins X-ray and NMR data of biological receptor-cocaine ...
Compagnone, Dario, Curini, Roberta, Del Carlo, Michele, Mascini, Marcello, Montero-Cabrera, Luis Alberto, Perez, German, Sergi, Manuel   +6 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Experiences and Senses: An Experimental Based Methodology for the Design Optimization

, 2014
Understanding users’ points of view is rapidly becoming an urgent issue for companies and designers, as well as User Experience and Experience Design proving to be of wide interest for academic research. This paper presents an experimental-based methodology aimed at guiding designers during product optimisation.
GATTI, ELIA, BORDEGONI, MONICA, CAMERE, SERENA   +2 more
openaire   +2 more sources

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

The application of experimental design methodology for the investigation of liquid radioactive waste treatment [PDF]

Nuclear Technology and Radiation Protection, 2017
The sorption properties of waste facade, brick, and asphalt sample towards Sr(II), Co(II), and Ni(II) ions from single and multicomponent solutions were investigated.
Šljivić-Ivanović Marija Z., Jelić Ivana V., Lončar Aleksandra M., Nikezić Dušan P., Dimović Slavko D., Lončar Boris B.   +5 more
doaj   +1 more source

The Design and Optimization of Ceramide NP-Loaded Liposomes to Restore the Skin Barrier

Pharmaceutics, 2023
The impairment of skin integrity derived from derangement of the orthorhombic lateral organization is mainly caused by dysregulation of ceramide amounts in the skin barrier.
Hümeyra Şahin Bektay, Ali Asram Sağıroğlu, Kübra Bozali, Eray Metin Güler, Sevgi Güngör   +4 more
doaj   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Design and Experiment of Double-Row Seed-Metering Device for Buckwheat Large Ridges

Agriculture, 2023
This article focuses on the low accuracy, poor stability, and other shortcomings of the traditional outer-groove buckwheat seed-metering wheel. A wheel-type large-ridge double-row seed-metering device with inner seed-filling holes was designed.
Xindan Qiao, Dequan Liu, Xiaolei Wang, Wang Li, Jiawei Wang, Decong Zheng   +5 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source