Results 71 to 80 of about 823,915 (314)

Developing a QFD-Based design-integrated structural analysis methodology

, 2012
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Design of the mechanical components greatly depends on their expected structural performances.
Mobasseri, Seyed Omid
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Conceptual design and optimization methodology for box wing aircraft [PDF]

, 2012
A conceptual design optimization methodology was developed for a medium range box wing aircraft. A baseline conventional cantilever wing aircraft designed for the same mis- sion and payload was also optimized alongside a baseline box wing aircraft.
Jemitola, Paul Olugbeji
core  

Exploring Alternative 3D FPGA Architectures: Design Methodology and CAD Tool Support

, 2007
This paper introduces a software supported methodology for exploring/evaluating 3D FPGA architectures. Two new CAD tools are developed: (i) the 3DPRO for placement and routing on 3D FPGAs and (ii) the 3DPower for power/energy estimation on such ...
Siozios, K., Siozios, K, Pavlidis, V, K. Siozios, Sotiriadis, K, Soudris, D, Pavlidis, V. F., K. Sotiriadis, Soudris, D., D. Soudris, Sotiriadis, K., V.F. Pavlidis   +11 more
core   +1 more source

Integration of Design of Experiments, Analysis of Variance and Response Surface Methodology in Assessing Heterogeneous Catalysts Processes: A Minireview

ChemistryOpen
This work reviews the application of Analysis of Variance (ANOVA), Design of Experiments (DOE), and Response Surface Methodology (RSM) in heterogeneous catalysis, based on an analysis of recent scientific literature.
Carlos Esteban Aristizábal‐Alzate, Eva Castillejos‐López, Ana Belén Dongil, Manuel Romero‐Sáez   +3 more
doaj   +1 more source

Statistical Analysis in Clinical and Experimental Medical Research: Simplified Guidance for Authors and Reviewers

Drug Design, Development and Therapy, 2023
Georgios D Panos,1,2 Frank M Boeckler3,4 1Department of Ophthalmology, Queen’s Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK; 2Division of Ophthalmology and Visual Sciences, School of Medicine, Faculty of Medicine and Health ...
Panos GD, Boeckler FM
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Development of an experiment-based robust design paradigm for multiple quality characteristics using physical programming

, 2007
The well-known quality improvement methodology, robust design, is a powerful and cost-effective technique for building quality into the design of products and processes.
Antony, Jiju, Cho, Byung Rae, Kovach, Jami   +2 more
core   +1 more source

Improved thermal design methodology for wind power converters

Journal of Modern Power Systems and Clean Energy, 2013
This paper presents an improved thermal design methodology for wind power converters. It combines analysis and experimental thermal design tools, including heat transfer correlations, flow network modeling (FNM), computational fluid dynamics (CFD), and ...
Fei Yang, Liang Guo
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source