Results 81 to 90 of about 2,245,571 (350)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Gas maldistribution in a fermenter stirred with multiple turbines [PDF]

, 2006
The study is focused on modeling of gas maldistribution of aerated liquid systems in a multiple impeller bioreactor. The phenomenon may or may not depend on column design.
Brienne, Jean Paul, Martinov, M., Montastruc, Ludovic, Nikov, Iordan   +3 more
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Integration of Design of Experiments, Analysis of Variance and Response Surface Methodology in Assessing Heterogeneous Catalysts Processes: A Minireview

ChemistryOpen
This work reviews the application of Analysis of Variance (ANOVA), Design of Experiments (DOE), and Response Surface Methodology (RSM) in heterogeneous catalysis, based on an analysis of recent scientific literature.
Carlos Esteban Aristizábal‐Alzate, Eva Castillejos‐López, Ana Belén Dongil, Manuel Romero‐Sáez   +3 more
doaj   +1 more source

Statistical Analysis in Clinical and Experimental Medical Research: Simplified Guidance for Authors and Reviewers

Drug Design, Development and Therapy, 2023
Georgios D Panos,1,2 Frank M Boeckler3,4 1Department of Ophthalmology, Queen’s Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK; 2Division of Ophthalmology and Visual Sciences, School of Medicine, Faculty of Medicine and Health ...
Panos GD, Boeckler FM
doaj  

Improved thermal design methodology for wind power converters

Journal of Modern Power Systems and Clean Energy, 2013
This paper presents an improved thermal design methodology for wind power converters. It combines analysis and experimental thermal design tools, including heat transfer correlations, flow network modeling (FNM), computational fluid dynamics (CFD), and ...
Fei Yang, Liang Guo
doaj   +1 more source

Pilot modeling, modal analysis, and control of large flexible aircraft [PDF]

, 1984
The issues to be addressed are threefold. The first deals with the question of whether dynamic aeroelastic effects can significantly impact piloted flight dynamics.
Schmidt, D. K.
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A comparison of analytical results for 20 K LOX/hydrogen instabilities [PDF]

Test data from NASA Lewis' Effect of Thrust Per Element on Combustion Stability Characteristics of Hydrogen-Oxygen Rocket Engines test program are used to validate two recently released stability analysis tools.
Breisacher, Kevin J., Klem, Mark D.
core   +1 more source