Results 71 to 80 of about 1,227,115 (260)

GEANT4 Target Simulations for Low Energy Medical Applications [PDF]

open access: yes, 2013
The GEANT4 code offers an extensive set of hadronic models for various projectiles and energy ranges. These models include theoretical, parameterized and, for low energy neutrons, data driven models.
Barlow, Roger   +4 more
core  

Effects of missing observations on predictive capability of central composite designs

open access: yes, 2014
Quite often in experimental work, many situations arise where some observations are lost or become unavailable due to some accidents or cost constraints.
Adebayo, Bamiduro Timothy   +3 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Efficient experimental designs for sigmoidal growth models [PDF]

open access: yes
For the Weibull- and Richards-regression model robust designs are determined by maximizing a minimum of D- or D1-efficiencies, taken over a certain range of the non-linear parameters.
Dette, Holger, Pepelyshev, Andrey
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Outperforming completely randomized designs. [PDF]

open access: yes
Bi-randomization designs have become increasingly popular in industry because some of the factors under investigation are often hard-to-change. It is well-known that the resulting compound symmetric error structure not only affects estimation and ...
Goos, Peter, Vandebroek, Martina
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

A cautionary note on the use of the Analysis of Covariance (ANCOVA) in classification designs with and without within-subject factors

open access: yesFrontiers in Psychology, 2015
A number of statistical textbooks recommend using an analysis of covariance (ANCOVA) to control for the effects of extraneous factors that might influence the dependent measure of interest. However, it is not generally recognized that serious problems of
Bruce A Schneider   +2 more
doaj   +1 more source

Compressive Measurement Designs for Estimating Structured Signals in Structured Clutter: A Bayesian Experimental Design Approach

open access: yes, 2013
This work considers an estimation task in compressive sensing, where the goal is to estimate an unknown signal from compressive measurements that are corrupted by additive pre-measurement noise (interference, or clutter) as well as post-measurement noise,
Haupt, Jarvis   +2 more
core   +1 more source

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