Results 131 to 140 of about 2,596,240 (298)

Nucleosynthesis in novae: experimental progress in the determination of nuclear reaction rates

, 2007
The sources of nuclear uncertainties in nova nucleosynthesis have been identified using hydrodynamical nova models. Experimental efforts have followed and significantly reduced those uncertainties.
Akira Ohnishi, Alain Coc, Kiyoshi Kato, Masayuki Y. Fujimoto, Shigeru Kubono, Takaya Nozawa, Takuma Suda, Toshitaka Kajino   +7 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Evolution in Response to Management Increases Invasiveness Among Experimental Populations of Duckweed (Lemna minor)

Evolutionary Applications
Numerous management methods are deployed to try to mitigate the destructive impact of weedy and invasive populations. Yet, such management practices may cause these populations to inadvertently evolve in ways that have consequence on their invasiveness ...
Taylor A. Zallek, Martin M. Turcotte
doaj   +1 more source

Genetics of adaptation: Experimental test of a biotic mechanism driving divergence in traits and genes

Evolution Letters, 2019
The genes underlying adaptations are becoming known, yet the causes of selection on genes—a key step in the study of the genetics of adaptation—remains uncertain.
Diana J. Rennison, Seth M. Rudman, Dolph Schluter   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The Endogenous Evolution of Market Institutions: An Experimental Investigation [PDF]

We study an experimental market in which the structure of the information flows is endogenized. When making an offer, traders choose not only the price at which they are prepared to trade, but also the subset of traders they want to inform about the ...
Kirchsteiger, G., Niederle, M., Potters, J.J.M.   +2 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Fitness landscape of substrate-adaptive mutations in evolved amino acid-polyamine-organocation transporters

eLife
The emergence of new protein functions is crucial for the evolution of organisms. This process has been extensively researched for soluble enzymes, but it is largely unexplored for membrane transporters, even though the ability to acquire new nutrients ...
Foteini Karapanagioti, Úlfur Águst Atlason, Dirk J Slotboom, Bert Poolman, Sebastian Obermaier   +4 more
doaj   +1 more source