Results 21 to 30 of about 2,583 (115)

NEK2 induces autophagy‐mediated bortezomib resistance by stabilizing Beclin‐1 in multiple myeloma

Molecular Oncology, 2020
NEK2 is associated with drug resistance in multiple cancers. Our previous studies indicated that high NEK2 confers inferior survival in multiple myeloma (MM); thus, a better understanding of the mechanisms by which NEK2 induces drug resistance in MM is ...
Jiliang Xia, Yanjuan He, Bin Meng, Shilian Chen, Jingyu Zhang, Xuan Wu, Yinghong Zhu, Yi Shen, Xiangling Feng, Yongjun Guan, Chunmei Kuang, Jiaojiao Guo, Qian Lei, Yangbowen Wu, Gang An, Guancheng Li, Lugui Qiu, Fenghuang Zhan, Wen Zhou   +18 more
doaj   +1 more source

Diagnostic imaging of experimental invasive pulmonary aspergillosis [PDF]

Medical Mycology, 2009
Pulmonary infiltrates in neutropenic hosts with invasive aspergillosis are caused by organism-mediated tissue injury, vascular invasion, and hemorrhagic infarction. Ultrafast computed tomography (UFCT) scanning reproducibly measures these lesions in experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits.
Thomas J, Walsh, Vidmantas, Petraitis, Ruta, Petraitiene, Jeffrey, Solomon, John D, Bacher, Lora, Greene, Margaret, Cotton, Andreas, Groll, Emmanuel, Roilides, Nilo, Avila, Vasilios, Pyrgos, Shmuel, Shoham   +11 more
openaire   +2 more sources

The chick embryo as an experimental system for melanoma cell invasion. [PDF]

PLoS ONE, 2013
BACKGROUND: A primary cutaneous melanoma will not kill the patient, but its metastases. Since in vitro studies on melanoma cells in 2-D cultures do often not reflect reality, 3-D models might come closer to the physiological situation in the patient ...
Christian Busch, Jelena Krochmann, Ulrich Drews   +2 more
doaj   +1 more source

Coupled tripartite investigation of breaker fluid invasion and impact on hydrocarbon recovery in sandstone reservoirs

Petroleum Research, 2023
Breaker fluids are designed to dissolve filter cakes by breaking their long-chain molecules, thereby removing solid deposits on the wellbore wall. Although breaker fluids are not intended to infiltrate the hydrocarbon reservoir, they can invade and cause
Stella I. Eyitayo, Kazeem A. Lawal, Marshall C. Watson, Oladoyin Kolawole, Ibrahim Abdullahi, Asekhame U. Yadua, Oluchukwu M. Okoh, Saka Matemilola, Tunde Alabi   +8 more
doaj   +1 more source

Imitating the effects of drilling fluid invasion on the strength behaviors of hydrate-bearing sediments: An experimental study

Frontiers in Earth Science, 2022
The drilling fluid invasion into hydrate-bearing sediments will change the geomechanical properties of the reservoir and may lead to uncontrolled geological disasters in the worst case.
Jun Pei, Jun Pei, Na Wei, Na Wei, Boning Zhang, Jinzhou Zhao, Jinzhou Zhao, Bjørn Kvamme, Richard B. Coffin, Haitao Li, Haitao Li, Haitao Li, Ruiling Bai, Ruiling Bai   +13 more
doaj   +1 more source

Optimized in vitro three-dimensional invasion assay for quantifying a wide range of cancer cell invasive behavior

STAR Protocols, 2022
Summary: We describe a three-dimensional (3D) in vitro assay for quantifying cancer cell invasion into a 3D microenvironment with defined biochemical and biophysical properties.
Samantha M. Hill, Marco Padilla-Rodriguez, Amber Clements, Jillian A. Sweetland, Sara S. Parker, Noel A. Warfel, Ghassan Mouneimne   +6 more
doaj   +1 more source

An Integrated Computational/Experimental Model of Tumor Invasion [PDF]

Cancer Research, 2006
Abstract The intracellular and extracellular dynamics that govern tumor growth and invasiveness in vivo remain poorly understood. Cell genotype and phenotype, and nutrient, oxygen, and growth factor concentrations are key variables. In previous work, using a reaction-diffusion mathematical model based on variables that directly describe ...
Hermann B, Frieboes, Xiaoming, Zheng, Chung-Ho, Sun, Bruce, Tromberg, Robert, Gatenby, Vittorio, Cristini   +5 more
openaire   +2 more sources

Screening and Identification of Novel Potential Biomarkers for Breast Cancer Brain Metastases

Frontiers in Oncology, 2022
Brain metastases represent a major cause of mortality among patients with breast cancer, and few effective targeted treatment options are currently available. Development of new biomarkers and therapeutic targets for breast cancer brain metastases (BCBM)
Lulu Wang, Lulu Wang, Lulu Wang, Dan Zeng, Qi Wang, Li Liu, Tao Lu, Yan Gao, Yan Gao, Yan Gao   +9 more
doaj   +1 more source

Genomic and phenotypic evolution of Escherichia coli in a novel citrate-only resource environment

eLife, 2020
Evolutionary innovations allow populations to colonize new ecological niches. We previously reported that aerobic growth on citrate (Cit+) evolved in an Escherichia coli population during adaptation to a minimal glucose medium containing citrate (DM25 ...
Zachary D Blount, Rohan Maddamsetti, Nkrumah A Grant, Sumaya T Ahmed, Tanush Jagdish, Jessica A Baxter, Brooke A Sommerfeld, Alice Tillman, Jeremy Moore, Joan L Slonczewski, Jeffrey E Barrick, Richard E Lenski   +11 more
doaj   +1 more source

The effects of microplastics size and type on entrapment by freshwater macrophytes under vertical and lateral deposition

Journal of Limnology
Marine and freshwater macrophytes are known to filter off microplastics from the water column; however, the effects of microplastic size and type on their retention by different macrophytes species have yet to be investigated.
Minli Wu, Yi Le Goh, Maxine A. D. Mowe, Peter A. Todd, Darren C.J. Yeo   +4 more
doaj   +1 more source