Results 91 to 100 of about 11,675,419 (289)

Insufficient physical activity: terminology and diagnostics. A review

open access: yesВестник восстановительной медицины
INTRODUCTION. Physical activity (PA) among the population in most countries around the world is steadily declining, increasing the risk of developing non-communicable diseases.
Maria V. Kuropatenko   +12 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Enhancement of systemic and lung-localized CD4+ T-cell immune responses by truncation of NS1 protein of a seasonal live influenza vaccine strain

open access: yesЖурнал микробиологии, эпидемиологии и иммунобиологии
Introduction. There is a large variety of licensed influenza vaccines worldwide, but their common limitation is rather narrow specificity and inability to protect against antigenic-drift variants of influenza virus. Therefore, optimization of immunogenic
Polina I. Prokopenko   +11 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The effect of the G141R egg-adaptive substitution on the biological properties of currently circulating B/Victoria-lineage influenza B viruses

open access: yesИнфекция и иммунитет
Despite the continuing interest in influenza infection and relevant pathogens, a significant number of publications in this field are devoted to influenza A viruses, while influenza B viruses receive less attention. In PubMed database, there are 10 times
Ekaterina A. Stepanova   +7 more
doaj   +1 more source

Boston University School of Medicine catalog [PDF]

open access: yes, 1901
Course catalog and informational material for the Boston University School of ...
Boston University School of Medicine
core  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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