Results 111 to 120 of about 11,675,419 (289)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The novel AMPA glutamate receptor antagonist zampaxidol attenuates binge eating potentiated by foot-shock stress

Research Results in Pharmacology
Introduction: Binge eating is linked to the brain reward system, modulated by glutamatergic projections affecting the mesolimbic dopamine pathway. This study explored AMPA receptor antagonists' effects on binge eating and stress-induced feeding behavior.
Andrey A. Lebedev, Aleksandr M. Potapkin, Maria A. Netesa, Sarng S. Pyurveev, Valerii E. Gmiro, Eugenii R. Bychkov, Maria A. Netesa, Dmitrii E. Anisimov, Nina S. Pestereva, Petr D. Shabanov   +9 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Practice of Experimental Medicine [PDF]

Proceedings of the Royal Society of Medicine, 1951
openaire   +2 more sources

Boston University School of Medicine catalog [PDF]

, 1900
Course catalog and informational material for the Boston University School of ...
Boston University School of Medicine
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Long-Acting Muscarinic Antagonists for the Treatment of Difficult-to-Treat and Severe Asthma: A Narrative Review Focusing on Inflammation from Bench to Bedside

Journal of Inflammation Research
Luigino Calzetta,1 Gian Marco Manzetti,2 Elena Pistocchini,2 Renato Federico Lauro,2 Shima Gholamalishahi,2 Mario Cazzola,2 Paola Rogliani2 1Unit of Respiratory Clinical Pharmacology, Department of Clinical Science and Translational Medicine, University ...
Calzetta L, Manzetti GM, Pistocchini E, Lauro RF, Gholamalishahi S, Cazzola M, Rogliani P   +6 more
doaj  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Boston University School of Medicine catalog [PDF]

, 1887
Course catalog and informational material for the Boston University School of ...
Boston University School of Medicine
core   +1 more source

The Child and Experimental Medicine [PDF]

BMJ, 1964
openaire   +2 more sources