Results 101 to 110 of about 11,675,419 (289)

From experimental biomodeling to personalized medicine

Acta Biomedica Scientifica, 2013
This article presents the results of experimental studies of adverse effects of environmental and occupational exposures on the morphofunctional state of the central nervous system in offspring rats.
V. S. Rukavishnikov, L. M. Sosedova, E. A. Kapustina, V. A. Vokina, E. A. Titov, N. L. Yakimova   +5 more
doaj  

Conserved linear B-cell peptides among the influenza A viral neuraminidases enhance the cross-protective potential of inactivated whole-virion influenza vaccine

Инфекция и иммунитет
Introduction. Influenza is a disease caused by a widespread virus with pandemic potential. Frequently, individuals vaccinated against seasonal influenza virus are still susceptible to the disease, indicating the need to improve the immunogenic potential ...
Tatiana S. Kotomina, I. A. Sychev, A. Ya. Rak, P.-F. Wong, A. V. Bazhina, I. N. Isakova-Sivak, L. G. Rudenko   +6 more
doaj   +1 more source

Renin–angiotensin system blockade alone or combined with ETA receptor blockade: effects on the course of chronic kidney disease in 5/6 nephrectomized Ren-2 transgenic hypertensive rats

Clinical and Experimental Hypertension, 2017
Background: Early addition of endothelin (ET) type A (ETA) receptor blockade to complex renin–angiotensin system (RAS) blockade has previously been shown to provide better renoprotection against progression of chronic kidney disease (CKD) in Ren-2 ...
Lenka Sedláková, Věra Čertíková Chábová, Šárka Doleželová, Petra Škaroupková, Libor Kopkan, Zuzana Husková, Lenka Červenková, Soňa Kikerlová, Ivana Vaněčková, Janusz Sadowski, Elzbieta Kompanowska-Jezierska, Petr Kujal, Herbert J. Kramer, Luděk Červenka   +13 more
doaj   +1 more source

Boston University School of Medicine catalog [PDF]

, 1912
Course catalog and informational material for the Boston University School of ...
Boston University School of Medicine
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

In vivo comparative analysis of live influenza vaccine candidates obtained by reverse genetics and classical reassortment

Инфекция и иммунитет
Difficulties identified in recent years while preparing reassortant live influenza vaccine (LAIV) strains related to the specific biological properties of currently circulating epidemic influenza viruses, necessitate the search for alternative ...
Natalie V. Larionova, Irina V. Kiseleva, Maya K. Vorsina, Anna K. Chistyakova, Ekaterina A. Stepanova, Larisa G. Rudenko, Ekaterina A. Bazhenova   +6 more
doaj   +1 more source

Boston University School of Medicine catalog [PDF]

, 1884
Course catalog and informational material for the Boston University School of ...
Boston University School of Medicine
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Boston University School of Medicine catalog [PDF]

, 1885
Course catalog and informational material for the Boston University School of ...
Boston University School of Medicine
core