Results 31 to 40 of about 57,721 (257)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Experimental modal analysis of an electric locomotive body
MATEC Web of Conferences, 2017 The study of the structural dynamics is essential for understanding and assessing of any engineering product performance, knowledge of dynamic structural response being fundamental to ensuring a sustainable and safe product functioning.
Manea Ion +5 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Dynamic Characteristics of the Amphitheatrum Flavium northern wall from traffic-induced vibrations
Annals of Geophysics, 2017 The effects of the traffic-induced vibrations on the external northern wall of the Amphitheatrum Flavium are studied with the two objectives of analyzing the amplitudes of such vibrations and extracting the dynamic characteristics of the structure as ...
Giovanni Bongiovanni +4 more
doaj +1 more source
Aerospace, 2023 The Loewner framework has recently been proposed for the system identification of mechanical systems, mitigating the limitations of current frequency domain fitting processes for the extraction of modal parameters.
Gabriele Dessena +5 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Effect of Boundary Conditions to Modal Parameters of Proportion Body
机车电传动, 2017 Boundary conditions are foundation of structural modal analysis. Different boundary conditions loading methods influence structural modal parameters via changing the structural stiffness.
SHI Yanmin +4 more
doaj
Influence of shrinkage on the dynamic properties of a cross-laminated timber panel
Results in EngineeringIn this paper, experimental modal analyses of a cross-laminated timber (CLT) panel with three layers subjected to free-free boundary conditions are presented.
Thomas Furtmüller +2 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source