Results 51 to 60 of about 28,665,543 (293)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

From Input-Output to Output-Only Modal Identification of Civil Engineering Structures [PDF]

open access: yes, 2005
This paper presents a brief characterization of the evolution of Experimental Modal Analysis in the Civil Engineering field, from Input-Output to Output-Only Modal Identification Techniques, taking particularly into account the experience of the authors ...
Elsa Caetano, Álvaro Cunha
core   +1 more source

Experimental modal analysis of the loudspeaker system

open access: yesArchives of Acoustics, 2014
This paper is concerned with an experimental modal analysis of a loudspeaker system. Based on Frequency Response Functions (FRFs) measured in about 500 points uniformly spaced on the front panel of the loudspeaker system several vibrations modes, mainly ...
E.B. SKRODZKA, A.P. SĘK
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Experimental modal and FEM analysis of a historical building [PDF]

open access: yesMATEC Web of Conferences
The CEDRAV building in Cerreto di Spoleto, originally a monastery, was built in the 14th century on the top of a rock ridge. The two seismic events that occurred on September 26th, 1997, with magnitude Ms=5.4 and Ms=6, respectively, caused some damages ...
Rinaldis Dario
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Modal Parameter Estimation of a PVC-product Cleaning Machine by means of Operational Modal Analysis [PDF]

open access: yes, 2009
The prototype of a machine tool for the fine machining of PVC window casings was recently developed and tested. Preliminary tests pointed out that excessive vibrations arise during the execution of some operative motion laws, possibly affecting the ...
TRONCOSSI, MARCO, RIVOLA, ALESSANDRO
core   +1 more source

Methods for modal parameters identification applied to CNC machine tool feed drives [PDF]

open access: yes
The paper presents a critical appraisal of existing methods for the identification of modal parameters (natural frequencies, damping ratios and mode shapes) for CNC machine tool feed drives.
Widiyarto, Muhammad Helmi Nur   +3 more
core   +4 more sources

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