Results 71 to 80 of about 61,802 (259)

Experimental Modal Analysis and Characterization of Additively Manufactured Polymers. [PDF]

open access: yesPolymers (Basel), 2022
Nguyen HT   +3 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Experimental dynamic analysis of the footbridge across Jizera River in Mladá Boleslav

open access: yesActa Polytechnica CTU Proceedings
The text of this submitted paper is devoted to the experimental dynamic analysis of the newly designed footbridge across the Jizera River in Mladá Boleslav.
Miroslav Čáp   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Modal Analysis and Test Research of Double Meshing Needle Teeth Cam Indexing Mechanism

open access: yesJixie chuandong, 2019
In order to explore the vibration characteristics of a new type of intermittent mechanism—double meshing needle teeth cam indexing mechanism,considering the complex connection relationship between various components, the finite element model of the ...
Mingtao Liu   +4 more
doaj  

Combined Estimation of Structural Displacement, Rotation and Strain Modes on a Scaled Glider

open access: yesApplied Sciences
Incorporating sensors such as microelectromechanical system (MEMS)-based inertial measurement units (IMUs) and strain gauges into aircraft structures has the potential to complement ground vibration testing results and improve the tracking of structural ...
Andres Jürisson   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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