Results 61 to 70 of about 28,665,543 (293)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Experimental and operational modal analysis in support of modal model updating - a test case
, 2019 The introduction of new equipment on board of aircraft requires fatigue evaluations to determine maintenance intervals. This is particularly true when complex assemblies are required to be installed in aircraft areas exposed to combined stresses, most ...
Coppotelli Giuliano +1 more
core
Cluster analysis of multiple experimental pain modalities
Pain, 2005 Identifying individual differences in pain is an important topic; however, little is known regarding patterns of responses across various experimental pain modalities. This study evaluated subgroups emerging from multiple experimental pain measures. One hundred and eighty-eight individuals (59.0% female) completed several psychological instruments and ...
University of Florida College of Dentistry, Division of Public Health Services and Research SW Archer Road, HSC D8-37, P.O. Box 100404 Gainesville, FL, USA ( host institution ) +7 more
openaire +3 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
New developments for experimental modal analysis of aircraft structures
MATEC Web of Conferences, 2015 This article presents an identification algorithm dedicated to the modal analysis of aircraft structures during flight-tests. More specifically, this algorithm was designed to process short duration tests carried out with multi-input excitations.
Vayssettes Jérémy, Mercère Guillaume
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Vibroacoustics of the piano soundboard : (Non)linearity and modal properties in the low- and mid-frequency ranges [PDF]
, 2013 The piano soundboard transforms the string vibration into sound and therefore, its vibrations are of primary importance for the sound characteristics of the instrument.
RÉBILLAT, Marc +2 more
core +1 more source
Modal analysis of a turbo-pump shaft: An innovative suspending method to improve the results
International Journal of Industrial Engineering and Production Research, 2008 Modal parameter extraction of high speed shafts is of critical importance in mechanical design of turbo-pumps. Due to the complex geometry and peripheral components of turbo-pumps, difficulties can arise in determination of modal parameters.
M.H. Sadegh +2 more
doaj
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source