Results 61 to 70 of about 349,012 (301)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Experimental modal and FEM analysis of a historical building [PDF]

MATEC Web of Conferences
The CEDRAV building in Cerreto di Spoleto, originally a monastery, was built in the 14th century on the top of a rock ridge. The two seismic events that occurred on September 26th, 1997, with magnitude Ms=5.4 and Ms=6, respectively, caused some damages ...
Rinaldis Dario
doaj   +1 more source

Modal test of the Viking orbiter [PDF]

A modal test of the Orbiter Development Test Modal (ODTM) has been conducted to verify, or update, the mathematical model used for load analysis. The approach used to assure the quality and validity of the experimental data is defined, the modal test is ...
Leppert, E. L., Miyakawa, R., Wada, B. K.   +2 more
core   +1 more source

Measurement and Evaluation Methods of Powertrain Vibrations [PDF]

, 2013
Tato bakalářská práce se zabývá metodami měření a vyhodnocování vibrací pohonných jednotek. Úvodem práce je vymezení základních veličin vibrací. Dále pojednává o experimentální modální analýze, způsobech buzení vibrací a měření odezev na dané buzení ...
Vítek, Michal
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Modal analysis of a turbo-pump shaft: An innovative suspending method to improve the results

International Journal of Industrial Engineering and Production Research, 2008
Modal parameter extraction of high speed shafts is of critical importance in mechanical design of turbo-pumps. Due to the complex geometry and peripheral components of turbo-pumps, difficulties can arise in determination of modal parameters.
M.H. Sadegh, S. Jafari, B. Nasseroleslami   +2 more
doaj  

Subsonic flutter analysis addition to NASTRAN [PDF]

, 1973
A subsonic flutter analysis capability has been developed for NASTRAN, and a developmental version of the program has been installed on the CDC 6000 series digital computers at the Langley Research Center.
Doggett, R. V., Jr., Harder, R. L.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

New developments for experimental modal analysis of aircraft structures

MATEC Web of Conferences, 2015
This article presents an identification algorithm dedicated to the modal analysis of aircraft structures during flight-tests. More specifically, this algorithm was designed to process short duration tests carried out with multi-input excitations.
Vayssettes Jérémy, Mercère Guillaume
doaj   +1 more source