Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Analysis of a Vibrating Beam Structure in the Context of Hands-On Teaching in Structural Dynamics
To demonstrate the difference between non-ideal experiments and idealized analytical models, bending vibrations of a frame structure have been analyzed in the context of hands-on teaching in structural dynamics. Both experimental modal analysis and model-
Thomas Kletschkowski
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Operational modal Analysis of the “Guglia Maggiore” of the “Duomo” in Milano
Every city has its own symbol, its very heart. In Milano this symbol, with its six centuries of history, is the Duomo. One of the most impressive buildings in Italy, this unique Gothic cathedral continues to awe citizens and travelers with its timeless ...
VANALI, MARCELLO +6 more
core
Modal Analysis and Test Research of Double Meshing Needle Teeth Cam Indexing Mechanism
In order to explore the vibration characteristics of a new type of intermittent mechanism—double meshing needle teeth cam indexing mechanism,considering the complex connection relationship between various components, the finite element model of the ...
Mingtao Liu +4 more
doaj
Combined Estimation of Structural Displacement, Rotation and Strain Modes on a Scaled Glider
Incorporating sensors such as microelectromechanical system (MEMS)-based inertial measurement units (IMUs) and strain gauges into aircraft structures has the potential to complement ground vibration testing results and improve the tracking of structural ...
Andres Jürisson +3 more
doaj +1 more source
Measurement of Acceleration Response Functions with Scalable Low-Cost Devices. An Application to the Experimental Modal Analysis. [PDF]
Magdaleno A +4 more
europepmc +1 more source
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Operational Modal Analysis of a Helicopter UAV from Flight Tests
The Operational Modal Analysis (OMA) could be used for the identification of the dynamics of aerospace vehicles, in terms of natural frequencies, damping ratios and mode shapes, during flight tests, using only the output responses due to the aerodynamic ...
GRAPPASONNI C +2 more
core
Vibration Energy Signal Information for Measure Dynamic Preferences of Ceramic Building Materials Using Experimental Modal Analysis Methodology. [PDF]
Żółtowski M +4 more
europepmc +1 more source

