Results 101 to 110 of about 8,549,066 (299)

Impact of variations in airborne microbiota on pneumonia infection: An exploratory study

Ecotoxicology and Environmental Safety
Background: Previous studies showed airborne bacteria affect pneumonia incidence, but specific impacts of bacterial communities on Klebsiella pneumoniae infection were unknown.
Li Zhou, Chenchen Song, Lianlian Zhao, Zhi Guo, Yuhan Lei, Yunlin Han, Kai Gao, Yanfeng Xu, Zhiguang Xiang, Baicun Li, Jianguo Guo   +10 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Progressive iron overload in middle-aged mice impairs olfactory function, triggers lipid oxidation and induces apoptosis

Frontiers in Pharmacology
IntroductionThis study aims to investigate the progressive impact of chronic iron overload on the olfactory bulb, a region significantly affected in early neurodegenerative diseases like Parkinson’s and Alzheimer’s. The focus is on understanding how iron
Lin Deng, Lin Deng, Lin Deng, Qihui Luo, Qihui Luo, Yucong Liu, Yucong Liu, Yao Wang, Yao Wang, Zongliang Xiong, Zongliang Xiong, Hongping Wang, Lu Zhao, Lanlan Jia, Lanlan Jia, Riyi Shi, Chao Huang, Chao Huang, Zhengli Chen, Zhengli Chen   +19 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Experimental Tests of the Standard Model [PDF]

, 1998
Four lectures on experimental test of the standard model presented at the Advanced Summer Institute on Techniques and Concepts of High Energy Physics.Comment: 46 page LaTeX with 35 figures included using epsf, requires crckapb.sty.
Nodulman, Larry
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Computational and Experimental Study on the effect of flow field distortion on the accuracy of the measurements made by anemometers on the Fino3 Meteorological mast [PDF]

, 2011
This paper reports on the experimental and computational modelling of the flow field around the FINO3 mast and provides an estimate of the amount of distortion that might be expected on instrumentation mounted on such a large structure. The open source C+
Fabre, Sylvie, Scanlon, Thomas, Stickland, Matthew   +2 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Experimental models [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 2005
openaire   +4 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source