Results 61 to 70 of about 8,549,066 (299)

Heterogeneous nuclear ribonucleoprotein K promotes the progression of lung cancer by inhibiting the p53‐dependent signaling pathway

Thoracic Cancer, 2022
Background Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is a nucleic acid‐binding protein. Reportedly, hnRNPK is overexpressed in many human tumors, and such overexpression is associated with poor prognosis, implicating the role of hnRNPK as an ...
Mengyuan Li, Xingjiu Yang, Guoxin Zhang, Le Wang, Ziwei Zhu, Wenlong Zhang, Hao Huang, Ran Gao   +7 more
doaj   +1 more source

Experimental study and model for healthy and pathological synovial fluid [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Goudoulas, TB, Kastrinakis, EG   +2 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches

MedComm – Future Medicine
Mitochondria are the primary energy hubs of cells and are critical for maintaining cellular functions. However, aging leads to a decline in mitochondrial efficiency.
Lanlan Jia, Ziyu Wei, Jinyuan Luoqian, Xi Wang, Chao Huang   +4 more
doaj   +1 more source

Combined transcriptome and metabolome analysis reveals the regulatory network of histidine kinase QseC in the two-component system of Glaesserella parasuis

Frontiers in Microbiology
IntroductionGlaesserella parasuis (G. parasuis) causes agent Glässer’s disease in swine. This study investigated the mechanism of QseC in G. parasuis.MethodsThe study utilized transcriptomic and metabolomic sequencing techniques.
Xuefeng Yan, Yuhong Zhou, Songwei Liu, Congwei Gu, Congwei Gu, Wudian Xiao, Wudian Xiao, Mingde Zhao, Mingde Zhao, Zehui Yu, Zehui Yu, Lvqin He, Lvqin He   +12 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Chronic methanol exposure induces cognitive impairment and Alzheimer's‐like pathology in rhesus monkeys

Animal Models and Experimental Medicine
Background The absence of effective animal models for sporadic Alzheimer's disease (AD) remains a pivotal barrier to therapy development. Because methanol metabolism produces endogenous formaldehyde, a neurotoxic agent linked to cognitive decline, this ...
Hongwei Li, Changhua Shi, Keya Li, Xinjing Fu, Ying Lyu, Yanfeng Xu, Yunlin Han, Wei Liang, Qin Chuan, Ling Zhang   +9 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Animal models of hypertension and concurrent organs injury

Animal Models and Experimental Medicine
Although hypertension is a frequently seen chronic condition across the world, its exact cause remains unclear. Animal models are beneficial for clarifying the pathogenic mechanism of hypertension and examining new treatments. An optimal animal model for
Ye Wang, Xiaoliang Jiang, Zhiwei Yang
doaj   +1 more source

The Association of Iron and the Pathologies of Parkinson’s Diseases in MPTP/MPP+-Induced Neuronal Degeneration in Non-human Primates and in Cell Culture

Frontiers in Aging Neuroscience, 2019
Despite much efforts in the last few decades, the mechanism of degeneration of dopamine (DA) neurons in the substantia nigra (SN) in Parkinson’s disease (PD) remains unclear.
Liangqin Shi, Liangqin Shi, Chao Huang, Chao Huang, Qihui Luo, Qihui Luo, Edmond Rogers, Yu Xia, Wentao Liu, Wentao Liu, Wenjing Ma, Wen Zeng, Li Gong, Jing Fang, Li Tang, Anchun Cheng, Riyi Shi, Zhengli Chen, Zhengli Chen, Zhengli Chen   +19 more
doaj   +1 more source