Results 31 to 40 of about 14,115,327 (313)

VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation

Disease Models & Mechanisms, 2019
Members of the VPS13 family are associated with various human diseases. In particular, the loss of function of VPS13A leads to chorea-acanthocytosis (ChAc), a rare neurodegenerative disease without available curative treatments.
Sandra Muñoz-Braceras, Alba R. Tornero-Écija, Olivier Vincent, Ricardo Escalante   +3 more
doaj   +1 more source

Experimental Models [PDF]

Stroke, 2009
Although many potential therapeutics have improved motor and cognitive function in animal models of experimental stroke, very few have been found to have similar beneficial effects in clinical trials. In this review, we examine the advantages and disadvantages of the currently available rodent models in the development of cellular therapies for stroke ...
openaire   +2 more sources

A Humanized Diet Profile May Facilitate Colonization and Immune Stimulation in Human Microbiota-Colonized Mice

Frontiers in Microbiology, 2020
BackgroundIn spite of the importance of the use of gnotobiotic mice for human fecal transfer, colonization efficiency and immune stimulation after human microbiota inoculation in mice are poorly studied compared to mouse microbiota inoculation. We tested
Isabel Moreno-Indias, Isabel Moreno-Indias, Isabel Moreno-Indias, Randi Lundberg, Randi Lundberg, Lukasz Krych, Stine Broeng Metzdorff, Witold Kot, Dorte Bratbo Sørensen, Dennis Sandris Nielsen, Camilla Hartmann Friis Hansen, Axel K. Hansen   +11 more
doaj   +1 more source

Evolution of the Experimental Models of Cholangiocarcinoma [PDF]

Cancers, 2020
Cholangiocarcinoma (CCA) is a rare, aggressive disease with poor overall survival. In advanced cases, surgery is often not possible or fails; in addition, there is a lack of effective and specific therapies. Multidisciplinary approaches and advanced technologies have improved the knowledge of CCA molecular pathogenesis, highlighting its extreme ...
Massa, Annamaria, Varamo, Chiara, Vita, Francesca, Tavolari, Simona, Peraldo-Neia, Caterina, Brandi, Giovanni, Rizzo, Alessandro, Cavalloni, Giuliana, Aglietta, Massimo   +8 more
openaire   +4 more sources

Animal Models of Traumatic Brain Injury

, 2016
Animal models of traumatic brain injury (TBI) have been the core of the research on the molecular, cellular, and functional effects of the disease. To be able to simulate the heterogeneous aspects of TBI several models have been designed.
Fredrik Clausen, Clausen, Fredrik,
core   +1 more source

Impact of quality and transparency in scientific writing on the reduction of animal usage in experimental protocols: a review based in pertinent literature

Frontiers in Veterinary Science
The irreproducibility in scientific research has become a critical issue. Despite the essential role of rigorous methodology in constructing a scientific article, more than half of publications, on average, are considered non-reproducible.
Matheus M. Neves, Sandra G. Klein, Ray C. Silva, Lucas M. M. Bernardes, Serena M. Malta, Thiago N. Vieira, Rafael B. Rosa, Isabela L. Lima, Flávia B. Ferreira, Murilo V. Silva, Murilo V. Silva   +10 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Cine experimental. Número 1 [PDF]

, 1944
Cine experimental (1944). Cine experimental. Número 1.
Cine experimental
core  

Traumatic Peripheral Nerve Injuries Experimental Models for Repair and Reconstruction

, 2019
Peripheral nerve injuries are difficult to treat, and the clinical outcome after surgical repair and reconstruction is still insufficient, particularly concerning recovery of sensory function.
Englund Johansson, Ulrica,, Dahlin, Lars B.,, Stenberg, Lena,, Johansson, Fredrik,, Lund University.   +4 more
core   +2 more sources

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source