Results 31 to 40 of about 2,221,895 (307)

On Zebrafish Disease Models and Matters of the Heart

Biomedicines, 2019
Coronary artery disease (CAD) is the leading form of cardiovascular disease (CVD), which is the primary cause of mortality worldwide. It is a complex disease with genetic and environmental risk factor contributions.
Panagiota Giardoglou, Dimitris Beis
doaj   +1 more source

Experimental Models for Psoriasis

Journal of Investigative Dermatology, 1990
Evidence suggests that inherent in skin of psoriatic subjects are cells, architectural structures, and/or mediators, which are, at a minimum, responsible for its hyperproliferative epidermis. An objective of our laboratory has been to establish an in vitro definition of this inherent aberration.
Krueger, G.G., Jorgensen, C.M.
openaire   +2 more sources

Biomarkers and experimental models for cancer immunology investigation

, 2023
The rapid advancement of tumor immunotherapies poses challenges for the tools used in cancer immunology research, highlighting the need for highly effective biomarkers and reproducible experimental models.
Pengming Pu, Pengrui Tang, Yongxin Zhou, Hengyi Xu, Ziqi Jia, Jiayi Li, Yufan Yang, Jianzhong Su, Fengshuo Liu, Jiaqi Liu, Tongxuan Shang, Yansong Huang, Yiwen Jiang   +12 more
core   +1 more source

A simple and low-cost environmental enrichment program improves the welfare of Calomys callosus, a species that adapts to animal facilities

Frontiers in Veterinary Science
An environmental enrichment protocol is essential for testing experimental models because it upholds animal welfare, aligns with ethical principles in animal experimentation, and reduces the number of animals needed.
Sandra Gabriela Klein, Tamires Soares de Assis, Gabriel Silva Pereira, Loyane Bertagnolli Coutinho, Renan Faria Guerra, Matheus Morais Neves, Flávia Batista Ferreira, Isabela Lemos de Lima, Richard Costa Polveiro, Eloisa Amália Vieira Ferro, Murilo Vieira da Silva, Murilo Vieira da Silva   +11 more
doaj   +1 more source

VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation

Disease Models & Mechanisms, 2019
Members of the VPS13 family are associated with various human diseases. In particular, the loss of function of VPS13A leads to chorea-acanthocytosis (ChAc), a rare neurodegenerative disease without available curative treatments.
Sandra Muñoz-Braceras, Alba R. Tornero-Écija, Olivier Vincent, Ricardo Escalante   +3 more
doaj   +1 more source

A Humanized Diet Profile May Facilitate Colonization and Immune Stimulation in Human Microbiota-Colonized Mice

Frontiers in Microbiology, 2020
BackgroundIn spite of the importance of the use of gnotobiotic mice for human fecal transfer, colonization efficiency and immune stimulation after human microbiota inoculation in mice are poorly studied compared to mouse microbiota inoculation. We tested
Isabel Moreno-Indias, Isabel Moreno-Indias, Isabel Moreno-Indias, Randi Lundberg, Randi Lundberg, Lukasz Krych, Stine Broeng Metzdorff, Witold Kot, Dorte Bratbo Sørensen, Dennis Sandris Nielsen, Camilla Hartmann Friis Hansen, Axel K. Hansen   +11 more
doaj   +1 more source

Experimental models of cardiac physiology and pathology.

, 2019
Experimental models of cardiac disease play a key role in understanding the pathophysiology of the disease and developing newtherapies. The features of the experimental models should reflect the clinical phenotype, which can have a wide spectrum ...
Roger J. Hajjar (5593883), Jae Gyun Oh (5593097), changwon kho (6376613), Kiyotake Ishikawa (585834)   +3 more
core   +1 more source

Investigating the therapeutic options for diabetes-associated male infertility as illustrated in animal experimental models

, 2022
Diabetes is a rising global health concern and an increasingly common cause of male infertility. Although the definitive pathophysiological mechanisms underpinning the association between diabetes and infertility is unclear, there are several animal ...
Narayan, Y., Minhas, S., Papatsoris, A., Buchholz, N., Khan, F., Tsampoukas, G., Tharakan, T., Cayetano, A.   +7 more
core   +1 more source

Experimental Models for Neurotrauma Research

, 2016
Physical trauma in the central nervous system (CNS) is usually the result of a number of forces in different directions and dimensions. A large number of experimental models have been developed to improve the possibilities to understand the outcome of ...
Davidsson, Johan,, Risling, Mårten
core   +2 more sources

Impact of quality and transparency in scientific writing on the reduction of animal usage in experimental protocols: a review based in pertinent literature

Frontiers in Veterinary Science
The irreproducibility in scientific research has become a critical issue. Despite the essential role of rigorous methodology in constructing a scientific article, more than half of publications, on average, are considered non-reproducible.
Matheus M. Neves, Sandra G. Klein, Ray C. Silva, Lucas M. M. Bernardes, Serena M. Malta, Thiago N. Vieira, Rafael B. Rosa, Isabela L. Lima, Flávia B. Ferreira, Murilo V. Silva, Murilo V. Silva   +10 more
doaj   +1 more source