Results 31 to 40 of about 5,848,146 (301)

Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]

, 2017
A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Aronica, Eleonora, Bauer, Sebastian, Bozzi, Yuri, Caleo, Matteo, Dingledine, Raymond, Gorter, Jan A., Henshall, David C., Kaminski, Rafal M., Kaufer, Daniela, Koh, Sookyong, Lã¶scher, Wolfgang, Louboutin, Jean-pierre, Mishto, Michele, Norwood, Braxton A., Palma, Eleonora, Poulter, Michael O., Terrone, Gaetano, Vezzani, Annamaria   +17 more
core   +5 more sources

Experimental models of epilepsy

Medicinski pregled, 2004
Introduction An epileptic seizure is a clinical event and epilepsy is rather a group of symptoms than a disease. The main features all epilepsies have in common include: spontaneous occurrence, repetitiveness, and ictal correlation within the EEG. Epilepsies are manifested with distinct EEG changes, requiring exact clinical definition and consequential
Olivera P, Stanojlović, Dragana P, Zivanović   +1 more
openaire   +3 more sources

On Zebrafish Disease Models and Matters of the Heart

Biomedicines, 2019
Coronary artery disease (CAD) is the leading form of cardiovascular disease (CVD), which is the primary cause of mortality worldwide. It is a complex disease with genetic and environmental risk factor contributions.
Panagiota Giardoglou, Dimitris Beis
doaj   +1 more source

A simple and low-cost environmental enrichment program improves the welfare of Calomys callosus, a species that adapts to animal facilities

Frontiers in Veterinary Science
An environmental enrichment protocol is essential for testing experimental models because it upholds animal welfare, aligns with ethical principles in animal experimentation, and reduces the number of animals needed.
Sandra Gabriela Klein, Tamires Soares de Assis, Gabriel Silva Pereira, Loyane Bertagnolli Coutinho, Renan Faria Guerra, Matheus Morais Neves, Flávia Batista Ferreira, Isabela Lemos de Lima, Richard Costa Polveiro, Eloisa Amália Vieira Ferro, Murilo Vieira da Silva, Murilo Vieira da Silva   +11 more
doaj   +1 more source

VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation

Disease Models & Mechanisms, 2019
Members of the VPS13 family are associated with various human diseases. In particular, the loss of function of VPS13A leads to chorea-acanthocytosis (ChAc), a rare neurodegenerative disease without available curative treatments.
Sandra Muñoz-Braceras, Alba R. Tornero-Écija, Olivier Vincent, Ricardo Escalante   +3 more
doaj   +1 more source

A Humanized Diet Profile May Facilitate Colonization and Immune Stimulation in Human Microbiota-Colonized Mice

Frontiers in Microbiology, 2020
BackgroundIn spite of the importance of the use of gnotobiotic mice for human fecal transfer, colonization efficiency and immune stimulation after human microbiota inoculation in mice are poorly studied compared to mouse microbiota inoculation. We tested
Isabel Moreno-Indias, Isabel Moreno-Indias, Isabel Moreno-Indias, Randi Lundberg, Randi Lundberg, Lukasz Krych, Stine Broeng Metzdorff, Witold Kot, Dorte Bratbo Sørensen, Dennis Sandris Nielsen, Camilla Hartmann Friis Hansen, Axel K. Hansen   +11 more
doaj   +1 more source

Modelling, identification and application of phenomenological constitutive laws over a large strain rate and temperature range [PDF]

, 2013
A review of the different phenomenological thermo-viscoplastic constitutive models often applied to forging and machining processes is presented. Several of the most common models have been identified using a large experimental database (Hor et al., 2013)
GERMAIN, Guénaël, HOR, Anis, LEBRUN, Jean-Lou, MOREL, Franck   +3 more
core   +8 more sources

Experimental Models of Cryptococcosis [PDF]

International Journal of Microbiology, 2012
Cryptococcosis is a life-threatening fungal disease that infects around one million people each year. Establishment and progression of disease involves a complex interplay between the fungus and a diverse range of host cell types. Over recent years, numerous cellular, tissue, and animal models have been exploited to probe this host-pathogen interaction.
Wilber Sabiiti, Robin C. May, E. Rhiannon Pursall   +2 more
openaire   +5 more sources

Impact of quality and transparency in scientific writing on the reduction of animal usage in experimental protocols: a review based in pertinent literature

Frontiers in Veterinary Science
The irreproducibility in scientific research has become a critical issue. Despite the essential role of rigorous methodology in constructing a scientific article, more than half of publications, on average, are considered non-reproducible.
Matheus M. Neves, Sandra G. Klein, Ray C. Silva, Lucas M. M. Bernardes, Serena M. Malta, Thiago N. Vieira, Rafael B. Rosa, Isabela L. Lima, Flávia B. Ferreira, Murilo V. Silva, Murilo V. Silva   +10 more
doaj   +1 more source

Metabolic alterations in experimental models of depression [PDF]

, 2016
Introduction: Major depressive disorder is one of the most prevalent psychiatric disorders and is associated with a severe impact on the personal functioning, thus with incurring significant direct and indirect costs.
Ionescu, Ecaterina, Manea, Mihnea C, Manea, Mirela, Paraschiv, George L, Paunica, Ioana, Puiu, Maria G., Purnichi, Traian, Tache, Simona   +7 more
core   +4 more sources