Results 21 to 30 of about 2,221,895 (307)

Immunization with a fusion protein vaccine candidate generated from truncated peptides of human enterovirus 71 protects mice from lethal enterovirus 71 infections

Virology Journal, 2020
Background Prophylactic vaccines are critical in preventing hand, foot, and mouth disease (HFMD) primarily caused by human enterovirus 71 (EV71) infection. Children aged less than 5 years are especially susceptible to EV71 infections.
Jiangning Liu, Binbin Zhao, Ling Xue, Jing Wu, Yanfeng Xu, Yongdong Liu, Chuan Qin   +6 more
doaj   +1 more source

Activation of the renal GLP‐1R leads to expression of Ren1 in the renal vascular tree

Endocrinology, Diabetes & Metabolism, 2021
The GLP‐1 receptor (GLP‐1R) in the kidney is expressed exclusively in vascular smooth muscle cells in arteries and arterioles. Downstream effects of the activation of the renal vascular GLP‐1R are elusive but may involve regulation of the renin ...
Katrine Dahl Bjørnholm, Maria Elm Ougaard, Gry Freja Skovsted, Lotte Bjerre Knudsen, Charles Pyke   +4 more
doaj   +1 more source

Updating Experimental Models of Diabetic Cardiomyopathy [PDF]

, 2015
Diabetic cardiomyopathy entails a serious cardiac dysfunction induced by alterations in structure and contractility of the myocardium. This pathology is initiated by changes in energy substrates and occurs in the absence of atherothrombosis, hypertension,
Egido de los Ríos, Jesús, A. Gómez-Hernández, Picatoste, Belén, Gómez-Hernández, A., Tuñón Fernández, José Luis, J. Tuñón, B. Picatoste, Lorenzo González, Óscar, J. Fuentes-Antrás, J. Egido, Ó. Lorenzo, Fuentes-Antras, J.   +11 more
core   +1 more source

Experimental models for nephropathy [PDF]

Journal of the Renin-Angiotensin-Aldosterone System, 2008
Nephropathy is a leading cause of morbidity and mortality and its prevalence is continuously increasing in industrialised nations. Nephropathy is characterised to varying degrees by nodular glomerulosclerosis, glomerular basement membrane thickness and mesangial expansion, leading to a decline in glomerular filtration rate, persistent elevated ...
Pitchal, Balakumar, Vishal Arvind, Chakkarwar, Vijay, Kumar, Akash, Jain, Jayarami, Reddy, Manjeet, Singh   +5 more
openaire   +2 more sources

Spatial Memory Dysfunction Induced by Vitamin C Deficiency Is Associated with Changes in Monoaminergic Neurotransmitters and Aberrant Synapse Formation

Antioxidants, 2018
Vitamin C (vitC) is important in the developing brain, acting both as an essential antioxidant and as co-factor in the synthesis and metabolism of monoaminergic neurotransmitters.
Stine Normann Hansen, Anne Marie V. Schou-Pedersen, Jens Lykkesfeldt, Pernille Tveden-Nyborg   +3 more
doaj   +1 more source

Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer’s disease: a meta-analytic review on potential mechanisms

Translational Neurodegeneration, 2020
Background Alzheimer’s disease is a neurodegenerative disorder. Therapeutically, a transplantation of bone marrow mesenchymal stem cells (BMMSCs) can play a beneficial role in animal models of Alzheimer’s disease.
Chuan Qin, Yalan Lu, Kewei Wang, Lin Bai, Guiying Shi, Yiying Huang, Yongning Li   +6 more
doaj   +1 more source

Oligosaccharide feed supplementation reduces plasma insulin in geldings with Equine Metabolic Syndrome

Frontiers in Microbiomes, 2023
BackgroundThe prevalence of Equine Metabolic Syndrome and insulin dysregulation is increasing in the horse population. Insulin dysregulation is a risk factor for laminitis, which has significant welfare consequences for the horse.
Alexandra von Münchow, Alexandra von Münchow, Sarah Torp Yttergren, Rasmus Riemer Jakobsen, Nanna Luthersson, Axel Kornerup Hansen, Frederikke Lindenberg   +6 more
doaj   +1 more source

Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model

Biomedicines, 2021
The successful development of effective treatments against nonalcoholic steatohepatitis (NASH) is significantly set back by the limited availability of predictive preclinical models, thereby delaying and reducing patient recovery.
Josephine Skat-Rørdam, David H. Ipsen, Stefan E. Seemann, Markus Latta, Jens Lykkesfeldt, Pernille Tveden-Nyborg   +5 more
doaj   +1 more source

Experimental models of epilepsy

Medicinski pregled, 2004
Introduction An epileptic seizure is a clinical event and epilepsy is rather a group of symptoms than a disease. The main features all epilepsies have in common include: spontaneous occurrence, repetitiveness, and ictal correlation within the EEG. Epilepsies are manifested with distinct EEG changes, requiring exact clinical definition and consequential
Olivera P, Stanojlović, Dragana P, Zivanović   +1 more
openaire   +3 more sources

Experimental models of leprosy

, 2017
Leprosy (Hansen’s disease) is a chronic granulomatous bacterial disease which mainly affects skin and peripheral nervous system. Leprosy is caused by the obligate intercellular pathogen known as Mycobacterium leprae.
A. A. Vorontsova, A. A. Kubanov, P. A. Kalinina, A. E. Karamova   +3 more
core   +1 more source