Results 21 to 30 of about 2,204,686 (267)

Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer’s disease: a meta-analytic review on potential mechanisms

Translational Neurodegeneration, 2020
Background Alzheimer’s disease is a neurodegenerative disorder. Therapeutically, a transplantation of bone marrow mesenchymal stem cells (BMMSCs) can play a beneficial role in animal models of Alzheimer’s disease.
Chuan Qin, Yalan Lu, Kewei Wang, Lin Bai, Guiying Shi, Yiying Huang, Yongning Li   +6 more
doaj   +1 more source

Oligosaccharide feed supplementation reduces plasma insulin in geldings with Equine Metabolic Syndrome

Frontiers in Microbiomes, 2023
BackgroundThe prevalence of Equine Metabolic Syndrome and insulin dysregulation is increasing in the horse population. Insulin dysregulation is a risk factor for laminitis, which has significant welfare consequences for the horse.
Alexandra von Münchow, Alexandra von Münchow, Sarah Torp Yttergren, Rasmus Riemer Jakobsen, Nanna Luthersson, Axel Kornerup Hansen, Frederikke Lindenberg   +6 more
doaj   +1 more source

Modelling Nonalcoholic Steatohepatitis In Vivo—A Close Transcriptomic Similarity Supports the Guinea Pig Disease Model

Biomedicines, 2021
The successful development of effective treatments against nonalcoholic steatohepatitis (NASH) is significantly set back by the limited availability of predictive preclinical models, thereby delaying and reducing patient recovery.
Josephine Skat-Rørdam, David H. Ipsen, Stefan E. Seemann, Markus Latta, Jens Lykkesfeldt, Pernille Tveden-Nyborg   +5 more
doaj   +1 more source

Experimental models in epilepsy

Neurología (English Edition), 2010
epilepsy is one of the neurological pathologies with the highest rate of incidence and with a significant number of negatives consequences. Current pharmacological treatments have an antiepileptic effect, allowing control over 70% of the patients, but they are not able to prevent the development of epileptogenesis from occurring.ee have reviewed the ...
M.E. Garcia Garcia, I. Garcia Morales, J. Matías Guiu   +2 more
openaire   +3 more sources

On Zebrafish Disease Models and Matters of the Heart

Biomedicines, 2019
Coronary artery disease (CAD) is the leading form of cardiovascular disease (CVD), which is the primary cause of mortality worldwide. It is a complex disease with genetic and environmental risk factor contributions.
Panagiota Giardoglou, Dimitris Beis
doaj   +1 more source

Experimental Models for Psoriasis

Journal of Investigative Dermatology, 1990
Evidence suggests that inherent in skin of psoriatic subjects are cells, architectural structures, and/or mediators, which are, at a minimum, responsible for its hyperproliferative epidermis. An objective of our laboratory has been to establish an in vitro definition of this inherent aberration.
Krueger, G.G., Jorgensen, C.M.
openaire   +2 more sources

A simple and low-cost environmental enrichment program improves the welfare of Calomys callosus, a species that adapts to animal facilities

Frontiers in Veterinary Science
An environmental enrichment protocol is essential for testing experimental models because it upholds animal welfare, aligns with ethical principles in animal experimentation, and reduces the number of animals needed.
Sandra Gabriela Klein, Tamires Soares de Assis, Gabriel Silva Pereira, Loyane Bertagnolli Coutinho, Renan Faria Guerra, Matheus Morais Neves, Flávia Batista Ferreira, Isabela Lemos de Lima, Richard Costa Polveiro, Eloisa Amália Vieira Ferro, Murilo Vieira da Silva, Murilo Vieira da Silva   +11 more
doaj   +1 more source

VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation

Disease Models & Mechanisms, 2019
Members of the VPS13 family are associated with various human diseases. In particular, the loss of function of VPS13A leads to chorea-acanthocytosis (ChAc), a rare neurodegenerative disease without available curative treatments.
Sandra Muñoz-Braceras, Alba R. Tornero-Écija, Olivier Vincent, Ricardo Escalante   +3 more
doaj   +1 more source

Experimental Models of Cryptococcosis [PDF]

International Journal of Microbiology, 2012
Cryptococcosis is a life-threatening fungal disease that infects around one million people each year. Establishment and progression of disease involves a complex interplay between the fungus and a diverse range of host cell types. Over recent years, numerous cellular, tissue, and animal models have been exploited to probe this host-pathogen interaction.
Wilber Sabiiti, Robin C. May, E. Rhiannon Pursall   +2 more
openaire   +5 more sources

A Humanized Diet Profile May Facilitate Colonization and Immune Stimulation in Human Microbiota-Colonized Mice

Frontiers in Microbiology, 2020
BackgroundIn spite of the importance of the use of gnotobiotic mice for human fecal transfer, colonization efficiency and immune stimulation after human microbiota inoculation in mice are poorly studied compared to mouse microbiota inoculation. We tested
Isabel Moreno-Indias, Isabel Moreno-Indias, Isabel Moreno-Indias, Randi Lundberg, Randi Lundberg, Lukasz Krych, Stine Broeng Metzdorff, Witold Kot, Dorte Bratbo Sørensen, Dennis Sandris Nielsen, Camilla Hartmann Friis Hansen, Axel K. Hansen   +11 more
doaj   +1 more source