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Evolution of the Experimental Models of Cholangiocarcinoma [PDF]
Cancers, 2020 Cholangiocarcinoma (CCA) is a rare, aggressive disease with poor overall survival. In advanced cases, surgery is often not possible or fails; in addition, there is a lack of effective and specific therapies. Multidisciplinary approaches and advanced technologies have improved the knowledge of CCA molecular pathogenesis, highlighting its extreme ...
Annamaria Massa +2 more
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Experimental models of demyelination and remyelination
Neurología (English Edition), 2020 Experimental animal models constitute a useful tool to deepen our knowledge of central nervous system disorders. In the case of multiple sclerosis, however, there is no such specific model able to provide an overview of the disease; multiple models covering the different pathophysiological features of the disease are therefore necessary.We reviewed the
Ulises Gómez-Pinedo
exaly +4 more sources
Effects of Autophagy-related Genes and Signal Pathways on Occurrence and Development of Oral Tumors
Zhongliu Fangzhi Yanjiu, 2021 Autophagy is a highly conservative cellular self-protective behavior dependent on lysosomes, and can be used as an important factor in promoting or preventing cancer, and its effect is related to the type and development of tumors.
XUE Rui +4 more
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Scientific Reports, 2022 Group sizes in an animal study are calculated from estimates on variation, effect, power and significance level. Much of the variation in glucose related parameters of the diet-induced obese (DIO) mouse model is due to inter-individual variation in gut ...
Valeriia Bondarenko +9 more
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Advantages and Progress of Using Chinese Hamsters to Construct Disease Models
Shiyan dongwu yu bijiao yixue, 2021 Chinese hamsters are experimental animals originally from China. They play an important role in experimental research on medicine and biology. They are widely used in life science research, such as genetics, infectious diseases, tissue culture ...
GAO Jiping +4 more
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Frontiers in Endocrinology, 2023 ObjectiveTo investigate the efficacy of rituximab in the treatment of idiopathic membranous nephropathy (IMN).MethodsA total of 77 patients with IMN diagnosed in both our hospital and other hospitals were included in this study; the patients were divided
Ping Chen +15 more
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Antioxidants, 2022 Vitamin C (vitC) deficiency has been associated with an increased risk of cardiovascular disease; while several putative mechanistic links have been proposed, functional evidence supporting a causal relationship is scarce.
Gry Freja Skovsted +5 more
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Animal Models and Experimental Medicine, 2021 Background Hematopoietic stem cells (HSC) maintain the hematopoietic system homeostasis through self‐renewal and multilineage differentiation potential. HSC are regulated by the microenvironment, cytokine signaling, and transcription factors.
Guiying Shi +6 more
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Vitamin C Deficiency May Delay Diet-Induced NASH Regression in the Guinea Pig
Antioxidants, 2021 Oxidative stress is directly linked to non-alcoholic fatty liver disease (NAFLD) and the progression to steaotohepatitis (NASH). Thus, a beneficial role of antioxidants in delaying disease progression and/or accelerating recovery may be expected, as ...
Josephine Skat-Rørdam +8 more
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Acute immune responses in zebrafish and evasive behavior of a parasite – who is winning?
Frontiers in Cellular and Infection Microbiology, 2023 The protozoan parasite Ichthyophthirius multifiliis is an economically important parasite for the aquaculture- and ornamental fish industry. The parasite is abundant worldwide and infects the skin, gills and fins of freshwater fish species.
Heidi Mathiessen +7 more
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