Results 11 to 20 of about 14,115,327 (313)

Experimental Models of Cryptococcosis [PDF]

International Journal of Microbiology, 2012
Cryptococcosis is a life-threatening fungal disease that infects around one million people each year. Establishment and progression of disease involves a complex interplay between the fungus and a diverse range of host cell types. Over recent years, numerous cellular, tissue, and animal models have been exploited to probe this host-pathogen interaction.
Wilber Sabiiti, Robin C. May, E. Rhiannon Pursall   +2 more
openaire   +7 more sources

Neuroprotective Effects of Ceftriaxone Involve the Reduction of Aβ Burden and Neuroinflammatory Response in a Mouse Model of Alzheimer’s Disease

Frontiers in Neuroscience, 2021
Ceftriaxone (CEF) is a safe and multipotent antimicrobial agent that possesses neuroprotective properties. Earlier, we revealed the restoration of cognitive function in OXYS rats with signs of Alzheimer’s disease (AD)-like pathology by CEF along with its
Maria A. Tikhonova, Tamara G. Amstislavskaya, Tamara G. Amstislavskaya, Ying-Jui Ho, Anna A. Akopyan, Michael V. Tenditnik, Marina V. Ovsyukova, Alim A. Bashirzade, Alim A. Bashirzade, Nina I. Dubrovina, Lyubomir I. Aftanas, Lyubomir I. Aftanas   +11 more
doaj   +1 more source

Histopathological Overview of Experimental Ulcer Models

, 2022
Histopathology is the process of examining tissue that includes all the changes, when a diseased tissue shows compared to a healthy group with a result of a histological observation.
Toktay, Erdem, Erdem Toktay, Selli, Jale, Jale Selli   +3 more
core   +1 more source

Identification and validation of viral antigens sharing sequence and structural homology with tumor-associated antigens (TAAs).

Journal for ImmunoTherapy of Cancer, 2021
Background The host’s immune system develops in equilibrium with both cellular self-antigens and non-self-antigens derived from microorganisms which enter the body during lifetime. In addition, during the years, a tumor may arise presenting to the immune
Luigi Buonaguro, Maria Lina Tornesello, Franco M Buonaguro, Concetta Ragone, Carmen Manolio, Beatrice Cavalluzzo, Angela Mauriello, Filippo Castiglione, Luigi Vitagliano, Emanuela Iaccarino, Menotti Ruvo, Maria Tagliamonte   +11 more
doaj   +1 more source

Experimental Models of Pancreatitis

Clinical Endoscopy, 2014
Acute pancreatitis is an inflammatory disease characterized by interstitial edema, inflammatory cell infiltration, and acinar cell necrosis, depending on its severity. Regardless of the extent of tissue injury, acute pancreatitis is a completely reversible process with evident normal tissue architecture after recovery. Its pathogenic mechanism has been
Hyun, Jong Jin, Lee, Hong Sik
openaire   +2 more sources

GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration

Neural Plasticity, 2019
In neurons, Glycogen Synthase Kinase-3β (GSK-3β) has been shown to regulate various critical processes underlying structural and functional synaptic plasticity.
Tomasz Jaworski, Ewa Banach-Kasper, Katarzyna Gralec   +2 more
doaj   +1 more source

Experimental models of stress

Dialogues in Clinical Neuroscience, 2006
Illustrating the complexity of the stress response and its multifaceted manifestations is the leading idea of this overview of experimental paradigms used for stress induction in laboratory animals. The description of key features of models based on naturalistic stressors, pharmacological challenges, and genomic manipulations is complemented by ...
Vladimir K, Patchev, Alexandre V, Patchev   +1 more
openaire   +3 more sources

Immunization with a fusion protein vaccine candidate generated from truncated peptides of human enterovirus 71 protects mice from lethal enterovirus 71 infections

Virology Journal, 2020
Background Prophylactic vaccines are critical in preventing hand, foot, and mouth disease (HFMD) primarily caused by human enterovirus 71 (EV71) infection. Children aged less than 5 years are especially susceptible to EV71 infections.
Jiangning Liu, Binbin Zhao, Ling Xue, Jing Wu, Yanfeng Xu, Yongdong Liu, Chuan Qin   +6 more
doaj   +1 more source

Editorial : experimental models of asthma [PDF]

, 2008
Since 2002, a workshop entitled “Asthma in animal models” has been held once a year in Hannover, Germany. It is organized by the Fraunhofer Institute of Toxicology and Experimental Medicine in collaboration with the collaborative research centre ...
Thomas Tschernig, David A Groneberg, Tschernig, Thomas, Braun, Armin, Groneberg, Jan David Alexander, Armin Braun   +5 more
core   +2 more sources

Activation of the renal GLP‐1R leads to expression of Ren1 in the renal vascular tree

Endocrinology, Diabetes & Metabolism, 2021
The GLP‐1 receptor (GLP‐1R) in the kidney is expressed exclusively in vascular smooth muscle cells in arteries and arterioles. Downstream effects of the activation of the renal vascular GLP‐1R are elusive but may involve regulation of the renin ...
Katrine Dahl Bjørnholm, Maria Elm Ougaard, Gry Freja Skovsted, Lotte Bjerre Knudsen, Charles Pyke   +4 more
doaj   +1 more source