Results 11 to 20 of about 2,221,895 (307)

Experimental Models of Dermatophytosis [PDF]

, 2021
Dermatophytosis is a superficial fungal infection of the keratinized structures of the host. Since the last decade, this mycosis became an important health concern due to an increasing prevalence and to the limited number and efficacy of available treatments.
Faway, Emilie, Thiry, Marc, Mignon, Bernard, Poumay, Yves   +3 more
core   +5 more sources

Experimental Models of Cryptococcosis [PDF]

International Journal of Microbiology, 2012
Cryptococcosis is a life-threatening fungal disease that infects around one million people each year. Establishment and progression of disease involves a complex interplay between the fungus and a diverse range of host cell types. Over recent years, numerous cellular, tissue, and animal models have been exploited to probe this host-pathogen interaction.
Wilber Sabiiti, Robin C. May, E. Rhiannon Pursall   +2 more
openaire   +7 more sources

Experimental models in epilepsy

Neurología (English Edition), 2010
epilepsy is one of the neurological pathologies with the highest rate of incidence and with a significant number of negatives consequences. Current pharmacological treatments have an antiepileptic effect, allowing control over 70% of the patients, but they are not able to prevent the development of epileptogenesis from occurring.ee have reviewed the ...
M.E. Garcia Garcia, I. Garcia Morales, J. Matías Guiu   +2 more
openaire   +4 more sources

Experimental models for ageing research [PDF]

, 2023
Ageing is a biological process caused by the malfunctioning of multiple cellular mechanisms, ascribable to nine hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing ...
Sirago, Giuseppe, Giacomello, Emiliana, Toniolo, Luana   +2 more
core   +3 more sources

Delayed Gut Colonization Shapes Future Allergic Responses in a Murine Model of Atopic Dermatitis

Frontiers in Immunology, 2021
Epidemiological studies have long reported that perturbations of the childhood microbiome increase the risk of developing allergies, but a causal relationship with atopic dermatitis remains unclear.
Amalie W. Arildsen, Line F. Zachariassen, Lukasz Krych, Axel K. Hansen, Camilla H. F. Hansen   +4 more
doaj   +1 more source

Pharmacokinetics of Repeated Oral Dosing with Coenzyme Q10 in Cavalier King Charles Spaniels with Myxomatous Mitral Valve Disease

Antioxidants, 2020
Coenzyme Q10 (Q10) is a mitochondrial cofactor and an antioxidant with the potential to combat oxidative stress in heart failure. This study aims to determine the pharmacokinetics of repeated oral dosing of Q10 in Cavalier King Charles Spaniels (CKCS ...
Liselotte B. Christiansen, Malene K. Morsing, Maria Josefine Reimann, Torben Martinussen, Zita Birlie, Anne Marie V. Schou-Pedersen, Jens Lykkesfeldt, Lisbeth H. Olsen   +7 more
doaj   +1 more source

Neuroprotective Effects of Ceftriaxone Involve the Reduction of Aβ Burden and Neuroinflammatory Response in a Mouse Model of Alzheimer’s Disease

Frontiers in Neuroscience, 2021
Ceftriaxone (CEF) is a safe and multipotent antimicrobial agent that possesses neuroprotective properties. Earlier, we revealed the restoration of cognitive function in OXYS rats with signs of Alzheimer’s disease (AD)-like pathology by CEF along with its
Maria A. Tikhonova, Tamara G. Amstislavskaya, Tamara G. Amstislavskaya, Ying-Jui Ho, Anna A. Akopyan, Michael V. Tenditnik, Marina V. Ovsyukova, Alim A. Bashirzade, Alim A. Bashirzade, Nina I. Dubrovina, Lyubomir I. Aftanas, Lyubomir I. Aftanas   +11 more
doaj   +1 more source

Identification and validation of viral antigens sharing sequence and structural homology with tumor-associated antigens (TAAs).

Journal for ImmunoTherapy of Cancer, 2021
Background The host’s immune system develops in equilibrium with both cellular self-antigens and non-self-antigens derived from microorganisms which enter the body during lifetime. In addition, during the years, a tumor may arise presenting to the immune
Luigi Buonaguro, Maria Lina Tornesello, Franco M Buonaguro, Concetta Ragone, Carmen Manolio, Beatrice Cavalluzzo, Angela Mauriello, Filippo Castiglione, Luigi Vitagliano, Emanuela Iaccarino, Menotti Ruvo, Maria Tagliamonte   +11 more
doaj   +1 more source

Experimental Models of Pancreatitis

Clinical Endoscopy, 2014
Acute pancreatitis is an inflammatory disease characterized by interstitial edema, inflammatory cell infiltration, and acinar cell necrosis, depending on its severity. Regardless of the extent of tissue injury, acute pancreatitis is a completely reversible process with evident normal tissue architecture after recovery. Its pathogenic mechanism has been
Hyun, Jong Jin, Lee, Hong Sik
openaire   +2 more sources

GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration

Neural Plasticity, 2019
In neurons, Glycogen Synthase Kinase-3β (GSK-3β) has been shown to regulate various critical processes underlying structural and functional synaptic plasticity.
Tomasz Jaworski, Ewa Banach-Kasper, Katarzyna Gralec   +2 more
doaj   +1 more source