Results 61 to 70 of about 5,848,146 (301)

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

Lysine-Specific Demethylase 1A as a Promising Target in Acute Myeloid Leukemia

Frontiers in Oncology, 2018
Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy characterized by the accumulation of incompletely differentiated progenitor cells (blasts) in the bone marrow and blood, and by suppression of normal hematopoiesis.
Daniela Magliulo, Daniela Magliulo, Rosa Bernardi, Samantha Messina   +3 more
doaj   +1 more source

Novel spontaneous myelodysplastic syndrome mouse model

Animal Models and Experimental Medicine, 2021
Background Myelodysplastic syndrome (MDS) is a group of disorders involving hemopoietic dysfunction leading to leukemia. Although recently progress has been made in identifying underlying genetic mutations, many questions still remain.
Weisha Li, Lin Cao, Mengyuan Li, Xingjiu Yang, Wenlong Zhang, Zhiqi Song, Xinpei Wang, Lingyan Zhang, Grant Morahan, Chuan Qin, Ran Gao   +10 more
doaj   +1 more source

Models of wave-function collapse, underlying theories, and experimental tests

, 2012
We describe the state of the art in preparing, manipulating and detecting coherent molecular matter. We focus on experimental methods for handling the quantum motion of compound systems from diatomic molecules to clusters or biomolecules.Molecular ...
Adler, S. L., Albert, D., Allen, L., Angelo Bassi, Arndt, M., Ashkin, A., Bell, J. S., Bell, J. S., Bell, J. S., Bohm, D., Breuer, H.-P., Bub, J., Christian, J., Deutsch, D., DeWitt, D. S., Dürr, D., Dürr, D., Feynman, R. P., Frenkel, A., Frenkel, A., Frenkel, A., Ghirardi, G., Ghirardi, G. C., Gikhman, I. I., Gisin, N., Goldin, G. A., Griffiths, R. B., Grishchuk, L. P., Hendrik Ulbricht, Holland, P. R., Joos, E., Karolyhazy, F., Karolyhazy, F., Karolyhazy, F., Karolyhazy, F., Karolyhazy, F., Kinjalk Lochan, Landau, L. D., Lyth, D. H., Maudlin, T., Myrvold, W. C., Omnès, R., Omnès, R., Pearle, P., Pearle, P., Pearle, P., Percival, I. C., Rauch, H., Schilpp, P. A., Schlosshauer, M., Seema Satin, Singh, T. P., Tejinder P. Singh, von Neumann, J., Wheeler, J. A.   +54 more
core   +2 more sources

Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright, Morgan A. Paul, Selena Murcia Mendez, Emily Jones, Lucille Lokko, Chelsea Heneghan, Nicholas Purol, Morgan Arnold, Rahela Aziz‐Bose, Colleen A. Kelly, Sandi L. Pruitt, Joanne Wolfe, Kira Bona, Puja J. Umaretiya   +13 more
wiley   +1 more source

Kidney Gastrin/CCKBR Attenuates Type 2 Diabetes Mellitus by Inhibiting SGLT2-Mediated Glucose Reabsorption through Erk/NF-κB Signaling Pathway [PDF]

Diabetes & Metabolism Journal
Background Both sodium-glucose cotransporters (SGLTs) and Na+/H+ exchangers (NHEs) rely on a favorable Na-electrochemical gradient. Gastrin, through the cholecystokinin B receptor (CCKBR), can induce natriuresis and diuresis by inhibiting renal NHEs ...
Xue Zhang, Yuhan Zhang, Yang Shi, Dou Shi, Min Niu, Xue Liu, Xing Liu, Zhiwei Yang, Xianxian Wu   +8 more
doaj   +1 more source

Experimental assessment of presumed filtered density function models [PDF]

, 2015
Measured filtered density functions (FDFs) as well as assumed beta distribution model of mixture fraction and “subgrid” scale (SGS) scalar variance, used typically in large eddy simulations, were studied by analysing experimental data, obtained from two ...
A. M. K. P. Taylor, Goodman J. W., N. Soulopoulos, V. Stetsyuk, Y. Hardalupas   +4 more
core   +1 more source

Financial Burden Associated With Hospitalisation Among Families of Childhood Brain Tumours in Australia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim, Natalie Bradford, David Brain, Sameera Senanayake, Sanjeewa Kularatna, Kate Young, Christine Cashion, Tim Hassall, Susanna Cramb   +8 more
wiley   +1 more source

Fine-Tuning Constraints on Supergravity Models

, 1999
We discuss fine-tuning constraints on supergravity models. The tightest constraints come from the experimental mass limits on two key particles: the lightest CP even Higgs boson and the gluino. We also include the lightest chargino which is relevant when
Carena, Dimopoulos, G.L. Kane, Kane, M. Bastero-Gil, Martin, Pierce, S.F. King   +7 more
core   +1 more source