Results 81 to 90 of about 2,221,895 (307)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Meeting on analgesic versus antiinflammatory agents: pharmacodynamics, experimental models and inter-relationships. Programme and abstracs

, 1991
SIGLEITItal
Istituto Superiore di Sanita', Rome (Italy)
core  

Brain arteriovenous malformations: A scoping review of experimental models

, 2021
Background: Brain arteriovenous malformations (bAVM) are one of the most complex vascular lesions in humans. Their understanding and treatment have been possible through the use of different experimental models.
Charbel Mounayer, Juan Pablo Cruz, Rodrigo Rivera, Aymeric Rouchaud, Catalina Merino-Osorio   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Whole Genome and Transcriptome Sequencing of Two Multi-Drug Resistant Mycobacterium tuberculosis Strains to Facilitate Illustrating Their Virulence in vivo

Frontiers in Cellular and Infection Microbiology, 2020
Mycobacterium tuberculosis clinical strains usually possess traits different from the laboratory strains like H37Rv, especially those clinical drug resistant strains.
Jun Tang, Jun Tang, Jun Tang, Jun Tang, Jun Tang, Zhihao Liu, Zhihao Liu, Zhihao Liu, Zhihao Liu, Zhihao Liu, Ya'nan Shi, Ya'nan Shi, Ya'nan Shi, Ya'nan Shi, Ya'nan Shi, Lingjun Zhan, Lingjun Zhan, Lingjun Zhan, Lingjun Zhan, Lingjun Zhan, Chuan Qin, Chuan Qin, Chuan Qin, Chuan Qin, Chuan Qin   +24 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An Introduction to Alternative Experimental Models in Monitoring Economic Failures [PDF]

, 2015
This research paper presents four alternative experimental models for monitoring economic failures. These models include the national production function (NP-Function), the multi-level trade creation and trade diversion analytical framework, the mega ...
Mario Arturo Ruiz Estrada, Muhammad Tahir, Tahir, Muhammad, Muhammad Muhammad, Ruiz Estrada, Mario Arturo   +4 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source